sentrin-specific protease 5; sentrin/SUMO-specific protease SENP5 (SENP5)

Function: - protease that catalyzes two essential functions in the SUMO pathway: a) processing of full-length SUMO3 to its mature form b) deconjugation of SUMO2 & SUMO3 from targeted proteins - has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates - required for cell division Structure: - belongs to the peptidase C48 family Compartment: nucleus, nucleolus

General

nuclear protein sentrin-specific protease (SUMO-specific protease)

Properties

SIZE: entity length = 755 aa MW = 87 kD COMPARTMENT: cell nucleus MOTIF: Protease {567-724} MOTIF: histidine residue {H646} aspartate residue {D663} cysteine residue {C713}

Database Correlations

OMIM 612845 UniProt Q96HI0 Pfam PF02902 Entrez Gene 205564 Kegg hsa:205564

References

UniProt :accession Q96HI0