Search
sentrin-specific protease 3; SUMO-1-specific protease 3; sentrin/SUMO-specific protease SENP3 (SENP3, SSP3, SUSP3)
Function:
- protease that releases SUMO2 & SUMO3 monomers from sumoylated substrates, but has only weak activity with SUMO1 conjugates
- deconjugates SUMO2 from MEF2D, which increases its transcriptional activation capability
- deconjugates SUMO2 & SUMO3 from CDCA8
- redox sensor that, when redistributed into nucleoplasm, can act as an effector to enhance HIF1A transcriptional activity by desumoylating EP300
- required for rRNA processing through deconjugation of SUMO2 & SUMO3 from nucleophosmin, NPM1
- on oxidative stress, SENP3 degradation is blocked by inhibition of its ubiquitination, which stabilizes it as it accumulates in the nucleoplasm
- binds to SUMO1 & SUMO3 (putative)
- component of some MLL1/MLL complex
- interacts with EP300, NPM1 & CDCA8
Structure:
- belongs to the peptidase C48 family
Compartment:
- nucleus, nucleolus, nucleoplasm
- redistributes between the nucleolus & the nucleoplasm in response to mild oxidative stress
Related
small ubiquitin-related modifier 1; SUMO-1; sentrin; ubiquitin-like protein SMT3C; SMT3 homolog 3; ubiquitin-homology domain protein PIC1; ubiquitin-like protein UBL1; GAP-modifying protein 1; GMP1 (SUMO1, SMT3C, SMT3H3, UBL1, OK/SW-cl43)
General
nuclear protein
phosphoprotein
sentrin-specific protease (SUMO-specific protease)
Properties
SIZE: entity length = 574 aa
MW = 65 kD
COMPARTMENT: cell nucleus
MOTIF: proline-rich region
SITE: 13-68
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S73}
Ser phosphorylation site {S75}
glutamate-rich region {76-92}
MOTIF: glutamate residue (SEVERAL)
nuclear translocation signal {125-128}
nuclear translocation signal {153-159}
Ser phosphorylation site {S169}
Thr phosphorylation site {T176}
Ser phosphorylation site {S181}
Ser phosphorylation site {S188}
proline-rich region
SITE: 192-195
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S212}
Ser phosphorylation site {S232}
Ser phosphorylation site {S253}
Ser phosphorylation site {S307}
Thr phosphorylation site {T353}
Protease {386-543}
MOTIF: histidine residue {H465}
aspartate residue {D482}
cysteine residue {C532}
Database Correlations
OMIM 612844
UniProt Q9H4L4
Pfam PF02902
Entrez Gene 26168
Kegg hsa:26168
References
UniProt :accession Q9H4L4