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sentinel lymph node procedure
Indications:
- breast cancer
- cancer of the vulva
- cervical cancer
- prostate cancer
- bladder cancer
- thyroid cancer
- head & neck cancer
- oral cancer [2]
- colon cancer
- rectal cancer
- gastric cancer
- non-small-cell lung cancer
- Merkel cell cancer
- cutaneous melanoma (intermediate-thickness)
Procedure:
- injection of blue dye or technetium-99m with gamma-probe localization allows a minimally invasive technique for detecting melanoma (or other cancer) metastases to local lymph nodes
- the nodes are then resected (intact) & checked for cancer
- radiation therapy may be directed at the site of the surgery & to nearby lymph nodes to destroy any remaining cancer cells
Laboratory:
- sentinel lymph nodes examined in cancer specimen (Loinc)
Related
superficial spreading melanoma
General
oncology
clinical procedure
References
- Color Atlas & Synopsis of Clinical Dermatology, Common
& Serious Diseases, 3rd ed, Fitzpatrick et al, McGraw Hill, NY,
1997, pg 978
- Civantos FJ et al.
Sentinel lymph node biopsy accurately stages the regional
lymph nodes for T1-T2 oral squamous cell carcinomas:
Results of a prospective multi-institutional trial.
J Clin Oncol 2010 Mar 10; 28:1395.
PMID: 20142602
- Wong SL, Faries MB, Kennedy EB, et al.
Sentinel Lymph Node Biopsy and Management of Regional
Lymph Nodes in Melanoma: American Society of Clinical
Oncology and Society of Surgical Oncology Clinical
Practice Guideline Update.
Ann Surg Oncol. 2018 Feb;25(2):356-377.
PMID: 29236202
https://www.ncbi.nlm.nih.gov/pubmed/29236202
- Sentinel Lymph Node Biopsy: Questions and Answers
National Cancer Institute
http://www.cancer.gov/cancertopics/factsheet/therapy/sentinel-node-biopsy