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senicapoc (ICA-17043)
Indications:
- sickle cell disease
Mechanism of action:
- long-acting Gardos-channel blocker
- inhibits K+ efflux
General
hematologic agent
amide
aromatic compound
Database Correlations
PUBCHEM cid=216327
References
- Ataga KI, Smith WR, De Castro LM, Swerdlow P et al
Efficacy and safety of the Gardos channel blocker, senicapoc
(ICA-17043), in patients with sickle cell anemia.
Blood. 2008 Apr 15;111(8):3991-7. Epub 2008 Jan 11.
PMID: 18192510
- Joiner CH.
Gardos pathway to sickle cell therapies?
Blood. 2008 Apr 15;111(8):3918-9.
PMID: 18434967