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semenogelin-2; semenogelin II; SGII (SEMG2)
Function:
- role in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions & ejaculated spermatozoa
- semenogelin-2 is thought to form both the 71 kD polypeptide &, in its glycosylated form, the 76 kD polypeptide
- interacts with SERPINA5
Structure: belongs to the semenogelin family
Compartment: secreted
Expression:
- expressed in seminal vesicles
- expressed, to a much lesser extent, in epididymis
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 582 aa
MW = 65 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
Repeat-rich region {70-559}
MOTIF: consensus repeat {70-129}
consensus repeat {141-200}
consensus repeat {201-260}
4 X 60 AA tandem repeats {261-500}
N-glycosylation site {N272}
consensus repeat {501-559}
Database Correlations
OMIM 182141
UniProt Q02383
Pfam PF05474
Entrez Gene 6407
Kegg hsa:6407
References
- UniProt :accession Q02383
- Protein Spotlight; Shackled sperm - Issue 62 of September 2005
http://web.expasy.org/spotlight/back_issues/sptlt062.shtml