Search
semaphorin-7A; semaphorin-L; sema L; semaphorin-K1; sema K1; John-Milton-Hargen human blood group Ag; JMH blood group antigen; CDw108; CD108 (SEMA7A, CD108, SEMAL)
Function:
- in monocytes stimulates
a) cytokine production
b) chemotaxis
c) superoxide release
- may have adhesion function;
- may modulate immune response
- may mediate neuronal function
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- cell membrane; lipid-anchor, GPI-anchor
Expression:
- erythrocytes
- lymphoblasts
- lymphocytes (low levels)
- expressed in placenta, testis, ovary, spleen, brain, spinal cord, lung, heart, adrenal gland, lymph nodes, thymus, intestine & kidney [1]
Pathology:
- deficiency may be associated with rare form of congenital dyserythropoietic anemia [2]
Laboratory:
- JMH Ab in serum/plasma
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glypiated protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 666 aa
MW = 75 kD
COMPARTMENT: plasma membrane
CELL-REGION: apical region
CELL: epithelial cell
MOTIF: signal sequence {1-44}
Sema {53-490}
MOTIF: N-glycosylation site {N105}
cysteine residue {C120}
MODIFICATION: cysteine residue {C126}
cysteine residue {C126}
MODIFICATION: cysteine residue {C120}
cysteine residue {C143}
MODIFICATION: cysteine residue {C152}
cysteine residue {C152}
MODIFICATION: cysteine residue {C143}
N-glycosylation site {N157}
N-glycosylation site {N258}
cysteine residue {C266}
MODIFICATION: cysteine residue {C366}
Cell attachment site {267-269}
cysteine residue {C291}
MODIFICATION: cysteine residue {C335}
N-glycosylation site {N330}
cysteine residue {C335}
MODIFICATION: cysteine residue {C291}
cysteine residue {C366}
MODIFICATION: cysteine residue {C266}
immunoglobulin superfamily domain {544-629}
MOTIF: cysteine residue {C566}
MODIFICATION: cysteine residue {C613}
N-glycosylation site {N602}
cysteine residue {C613}
MODIFICATION: cysteine residue {C566}
glycosyl phosphatidylinositol [GPI] membrane anchor {N648}
Database Correlations
OMIM 607961
UniProt O75326
PFAM correlations
Entrez Gene 8482
Kegg hsa:8482
References
- Entrez Gene :accession 8482
- http://www.pathologyoutlines.com/cdmarkers.html
21 June 2005
- UniProt :accession O75326
- dbRBC/BGMUT; Note: Blood group antigen gene mutation database
http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=jmh
- SeattleSNPs
http://pga.gs.washington.edu/data/sema7a/