Search
Semaphorin-6D (SEMA6D, KIAA1479)
Function:
- growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro
- may be a stop signal for DRG neurons in their target areas, & possibly also for other neurons
- role in maintenance & remodeling of neuronal connections
Structure:
- belongs to the semaphorin family
- contains 1 PSI domain
- contains 1 Sema domain
Compartment: isoforms 1-5: cell membrane isoform 7: cytoplasm
Alternative splicing: named isoforms=7
General
glycoprotein
membrane protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: MW = 120 kD
entity length = 1073 aa
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-20}
Sema {27-512}
MOTIF: N-glycosylation site {N51}
cysteine residue {C108}
MODIFICATION: cysteine residue {C118}
cysteine residue {C118}
MODIFICATION: cysteine residue {C108}
cysteine residue {C136}
MODIFICATION: cysteine residue {C145}
cysteine residue {C145}
MODIFICATION: cysteine residue {C136}
cysteine residue {C259}
MODIFICATION: cysteine residue {C370}
N-glycosylation site {N283}
cysteine residue {C284}
MODIFICATION: cysteine residue {C329}
cysteine residue {C329}
MODIFICATION: cysteine residue {C284}
cysteine residue {C370}
MODIFICATION: cysteine residue {C259}
N-glycosylation site {N435}
N-glycosylation site {N461}
PSI {514-569}
N-glycosylation site {N631}
transmembrane domain {663-683}
Database Correlations
OMIM 609295
UniProt Q8NFY4
PFAM correlations
Entrez Gene 80031
Kegg hsa:80031
References
UniProt :accession Q8NFY4