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semaphorin-6C; semaphorin-Y; sema Y (SEMA6C KIAA1869 SEMAY)
Function:
- growth cone collapsing activity on dorsal root ganglion (DRG) neurons in vitro
- may be a stop signal for the DRG neurons in their target areas, & possibly also for other neurons
- may alsoplay role in maintenance & remodeling of neuronal connections
Structure:
- belongs to the semaphorin family
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=3
Expression:
- in adult tissues, expressed only in skeletal muscle
General
glycoprotein
membrane protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 930 aa
MW = 100 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-24}
Sema {30-516}
MOTIF: N-glycosylation site {N70}
cysteine residue {C111}
MODIFICATION: cysteine residue {C121}
cysteine residue {C121}
MODIFICATION: cysteine residue {C111}
cysteine residue {C139}
MODIFICATION: cysteine residue {C148}
cysteine residue {C148}
MODIFICATION: cysteine residue {C139}
cysteine residue {C262}
MODIFICATION: cysteine residue {C373}
N-glycosylation site {N286}
cysteine residue {C287}
MODIFICATION: cysteine residue {C332}
cysteine residue {C332}
MODIFICATION: cysteine residue {C287}
cysteine residue {C373}
MODIFICATION: cysteine residue {C262}
N-glycosylation site {N437}
transmembrane domain {605-625}
proline-rich region
SITE: 662-667
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 752-755
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 609294
UniProt Q9H3T2
PFAM correlations
Entrez Gene 10500
Kegg hsa:10500
References
- UniProt :accession Q9H3T2
- Entrez Gene :accession 10500