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semaphorin-6B; semaphorin-Z; sema Z (SEMA6B, SEMAN, SEMAZ, UNQ1907/PRO4353)
Function:
- may play a role in both peripheral nervous system & central nervous system development (putative)
Structure:
- belongs to the semaphorin family
- contains 1 sema domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=2
- additional isoforms seem to exist
General
glycoprotein
membrane protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 888 aa
MW = 95 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-25}
Sema {31-523}
MOTIF: N-glycosylation site {N74}
cysteine residue {C116}
MODIFICATION: cysteine residue {C126}
cysteine residue {C126}
MODIFICATION: cysteine residue {C116}
cysteine residue {C144}
MODIFICATION: cysteine residue {C153}
cysteine residue {C153}
MODIFICATION: cysteine residue {C144}
N-glycosylation site {N155}
N-glycosylation site {N167}
cysteine residue {C267}
MODIFICATION: cysteine residue {C378}
N-glycosylation site {N291}
cysteine residue {C292}
MODIFICATION: cysteine residue {C337}
cysteine residue {C337}
MODIFICATION: cysteine residue {C292}
cysteine residue {C378}
MODIFICATION: cysteine residue {C267}
N-glycosylation site {N386}
N-glycosylation site {N441}
N-glycosylation site {N462}
transmembrane domain {604-624}
glycine-rich region {661-674}
Database Correlations
OMIM 608873
UniProt Q9H3T3
PFAM correlations
Entrez Gene 10501
Kegg hsa:10501
References
- UniProt :accession Q9H3T3
- Entrez Gene :accession 10501