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semaphorin-6A; semaphorin VIA; sema VIA; semaphorin-6A-1; SEMA6A-1 (SEMA6A, KIAA1368, SEMAQ)
Function:
- cell surface receptor for PLXNA2
- role in cell-cell signaling
- required for normal granule cell migration in the developing cerebellum
- promotes reorganization of the actin cytoskeleton
- role in axon guidance in the developing CNS
- can act as repulsive axon guidance cue
- repulsive action towards migrating granular neurons
- may play a role in channeling sympathetic axons into the sympathetic chains & controlling the temporal sequence of sympathetic target innervation
- active as a homodimer or oligomer
- the SEMA6A homodimer interacts with a PLXNA2 homodimer, giving rise to a heterotetramer (putative)
- interacts with EVL
Structure:
- belongs to the semaphorin family
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- plasma membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
General
glycoprotein
human longevity protein
membrane protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 1030 aa
MW = 114 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-18}
Sema {24-512}
MOTIF: N-glycosylation site {N33}
N-glycosylation site {N49}
N-glycosylation site {N65}
cysteine residue {C107}
MODIFICATION: cysteine residue {C117}
cysteine residue {C117}
MODIFICATION: cysteine residue {C107}
cysteine residue {C135}
MODIFICATION: cysteine residue {C144}
cysteine residue {C144}
MODIFICATION: cysteine residue {C135}
cysteine residue {C258}
MODIFICATION: cysteine residue {C369}
N-glycosylation site {N282}
cysteine residue {C283}
MODIFICATION: cysteine residue {C328}
cysteine residue {C328}
MODIFICATION: cysteine residue {C283}
cysteine residue {C369}
MODIFICATION: cysteine residue {C258}
N-glycosylation site {N434}
N-glycosylation site {N461}
cysteine residue {C477}
MODIFICATION: cysteine residue {C506}
cysteine residue {C506}
MODIFICATION: cysteine residue {C477}
cysteine residue {C515}
MODIFICATION: cysteine residue {C533}
cysteine residue {C521}
MODIFICATION: cysteine residue {C568}
cysteine residue {C525}
MODIFICATION: cysteine residue {C542}
cysteine residue {C533}
MODIFICATION: cysteine residue {C515}
cysteine residue {C542}
MODIFICATION: cysteine residue {C525}
cysteine residue {C568}
MODIFICATION: cysteine residue {C521}
transmembrane domain {650-670}
proline-rich region
SITE: 792-819
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 605885
UniProt Q9H2E6
PFAM correlations
Entrez Gene 57556
Kegg hsa:57556
References
- UniProt :accession Q9H2E6
- Entrez Gene :accession 57556