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semaphorin-4F; semaphorin-W; sema W; semaphorin-M; sema M (SEMA4F SEMAM SEMAW)
Function:
- growth cone collapse activity against retinal ganglion-cell axons (putative)
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=2; long short
General
glycoprotein
membrane protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 770 aa
MW = 84 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-34}
Sema {42-510}
MOTIF: N-glycosylation site {N64}
cysteine residue {C112}
MODIFICATION: cysteine residue {C122}
cysteine residue {C122}
MODIFICATION: cysteine residue {C112}
N-glycosylation site {N133}
cysteine residue {C140}
MODIFICATION: cysteine residue {C149}
cysteine residue {C149}
MODIFICATION: cysteine residue {C140}
cysteine residue {C273}
MODIFICATION: cysteine residue {C384}
cysteine residue {C297}
MODIFICATION: cysteine residue {C343}
cysteine residue {C343}
MODIFICATION: cysteine residue {C297}
cysteine residue {C384}
MODIFICATION: cysteine residue {C273}
N-glycosylation site {N509}
PSI {512-563}
immunoglobulin superfamily domain {580-635}
MOTIF: cysteine residue {C587}
MODIFICATION: cysteine residue {C628}
cysteine residue {C628}
MODIFICATION: cysteine residue {C587}
transmembrane domain {660-680}
Database Correlations
OMIM 603706
UniProt O95754
PFAM correlations
Entrez Gene 10505
Kegg hsa:10505
References
- UniProt :accession O95754
- Entrez Gene :accession 10505