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semaphorin-4D; BB18; A8; GR3; CD100 (SEMA4D, CD100, SEMAJ)
Function:
- may play functional role in immune system & nervous system
- induces B cell aggregation
- binds plexin B1
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- membrane; single-pass type 1 membrane protein
Expression:
- expressed in skeletal muscle, spleen, thymus, peripheral blood lymphocytes > testes, brain, kidney, small intestine, prostate, heart, placenta, lung, pancreas
- not expressed in colon, liver, immature bone marrow cells
Interactions
molecular events
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
membrane protein
phosphoprotein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 862 aa
MW = 96 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-21}
Sema {22-500}
MOTIF: N-glycosylation site {N49}
N-glycosylation site {N74}
N-glycosylation site {N77}
cysteine residue {C97}
MODIFICATION: cysteine residue {C108}
cysteine residue {C108}
MODIFICATION: cysteine residue {C97}
cysteine residue {C126}
MODIFICATION: cysteine residue {C135}
cysteine residue {C135}
MODIFICATION: cysteine residue {C126}
N-glycosylation site {N139}
N-glycosylation site {N191}
Ser phosphorylation site {S195}
cysteine residue {C257}
MODIFICATION: cysteine residue {C370}
cysteine residue {C281}
MODIFICATION: cysteine residue {C326}
cysteine residue {C326}
MODIFICATION: cysteine residue {C281}
N-glycosylation site {N329}
cysteine residue {C370}
MODIFICATION: cysteine residue {C257}
N-glycosylation site {N379}
N-glycosylation site {N419}
PSI {502-551}
MOTIF: cysteine residue {C503}
MODIFICATION: cysteine residue {C520}
cysteine residue {C509}
MODIFICATION: cysteine residue {C553}
cysteine residue {C512}
MODIFICATION: cysteine residue {C529}
cysteine residue {C520}
MODIFICATION: cysteine residue {C503}
cysteine residue {C529}
MODIFICATION: cysteine residue {C512}
cysteine residue {C553}
MODIFICATION: cysteine residue {C509}
immunoglobulin superfamily domain {554-636}
MOTIF: cysteine residue {C576}
MODIFICATION: cysteine residue {C624}
N-glycosylation site {N613}
cysteine residue {C624}
MODIFICATION: cysteine residue {C576}
N-glycosylation site {N632}
transmembrane domain {735-755}
Database Correlations
OMIM 601866
UniProt Q92854
PFAM correlations
Entrez Gene 10507
Kegg hsa:10507
References
- Uniprot Q92854
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org//genes/SEMA4DID42255ch9q22.html
- http://www.pathologyoutlines.com/cd100247.html
21 June 2005
Component-of
molecular complex