semaphorin-4C (SEMA4C KIAA1739 SEMAI UNQ5855/PRO34487)

Function: - probable signaling receptor which may play a role in myogenic differentiation through activation of the stress-activated MAPK cascade - interacts (via PDZ-binding motif) with GIPC (via PDZ domain) (putative) - interacts with NCDN - interacts (via the PDZ-binding motif) with DLG4 (putative) Structure: - belongs to the semaphorin family - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 1 PSI domain - contains 1 sema domain Compartment: - cell junction, synapse, postsynaptic cell membrane, postsynaptic density; single-pass type 1 membrane protein (putative) - cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; single-pass type 1 membrane protein

General

glycoprotein phosphoprotein secreted protein semaphorin or semaphorin/collapsin family protein

Properties

SIZE: entity length = 833 aa MW = 93 kD COMPARTMENT: cytoplasm cellular membrane MOTIF: signal sequence {1-20} Sema {30-497} MOTIF: domain {46-489} cysteine residue {C99} MODIFICATION: cysteine residue {C110} N-glycosylation site {N106} cysteine residue {C110} MODIFICATION: cysteine residue {C99} N-glycosylation site {N121} cysteine residue {C128} MODIFICATION: cysteine residue {C137} cysteine residue {C137} MODIFICATION: cysteine residue {C128} cysteine residue {C261} MODIFICATION: cysteine residue {C370} cysteine residue {C285} MODIFICATION: cysteine residue {C330} N-glycosylation site {N310} cysteine residue {C330} MODIFICATION: cysteine residue {C285} cysteine residue {C370} MODIFICATION: cysteine residue {C261} N-glycosylation site {N419} PSI {499-551} MOTIF: N-glycosylation site {N522} immunoglobulin superfamily domain {556-644} MOTIF: N-glycosylation site {N564} transmembrane domain {664-684} proline-rich region SITE: 708-773 MOTIF: proline residue (SEVERAL) PDZ recognition motif NAME: PDZ recognition motif SITE: 830-833 FOR-BINDING-VIA: PDZ domain MOTIF: Ser phosphorylation site {S832}

Database Correlations

OMIM 604462 UniProt Q9C0C4 PFAM correlations Entrez Gene 54910 Kegg hsa:54910