Search
semaphorin-4B (SEMA4B, KIAA1745, SEMAC, UNQ749/PRO1480)
Function:
- inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- membrane; single-pass type 1 membrane protein
Alternative splicing:
- named isoforms=2
General
glycoprotein
phosphoprotein
secreted protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 832 aa
MW = 92 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-38}
Sema {42-518}
MOTIF: N-glycosylation site {N64}
N-glycosylation site {N91}
cysteine residue {C115}
MODIFICATION: cysteine residue {C126}
cysteine residue {C126}
MODIFICATION: cysteine residue {C115}
cysteine residue {C144}
MODIFICATION: cysteine residue {C153}
cysteine residue {C153}
MODIFICATION: cysteine residue {C144}
N-glycosylation site {N160}
cysteine residue {C281}
MODIFICATION: cysteine residue {C394}
cysteine residue {C305}
MODIFICATION: cysteine residue {C354}
cysteine residue {C354}
MODIFICATION: cysteine residue {C305}
cysteine residue {C394}
MODIFICATION: cysteine residue {C281}
N-glycosylation site {N405}
PSI {520-574}
MOTIF: N-glycosylation site {N520}
immunoglobulin superfamily domain {599-658}
MOTIF: cysteine residue {C606}
MODIFICATION: cysteine residue {C651}
N-glycosylation site {N625}
cysteine residue {C651}
MODIFICATION: cysteine residue {C606}
transmembrane domain {713-733}
proline-rich region
SITE: 753-776
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S813}
Ser phosphorylation site {S825}
Database Correlations
UniProt Q9NPR2
PFAM correlations
References
- UniProt :accession Q9NPR2
- Entrez Gene :accession 10509