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semaphorin-4A; semaphorin-B; sema B (SEMA4A, SEMAB, SEMB, UNQ783/PRO1317)
Function:
- inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- membrane; single-pass type 1 membrane protein (putative)
Pathology:
- defects in SEMA4A are the cause of
a) retinitis pigmentosa type 35
b) cone-rod dystrophy type 10
General
glycoprotein
membrane protein
phosphoprotein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 761 aa
MW = 84 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-32}
Sema {36-494}
MOTIF: cysteine residue {C113}
MODIFICATION: cysteine residue {C124}
N-glycosylation site {N120}
cysteine residue {C124}
MODIFICATION: cysteine residue {C113}
N-glycosylation site {N135}
cysteine residue {C142}
MODIFICATION: cysteine residue {C151}
cysteine residue {C151}
MODIFICATION: cysteine residue {C142}
cysteine residue {C269}
MODIFICATION: cysteine residue {C379}
cysteine residue {C293}
MODIFICATION: cysteine residue {C339}
cysteine residue {C339}
MODIFICATION: cysteine residue {C293}
cysteine residue {C379}
MODIFICATION: cysteine residue {C269}
PSI {496-548}
MOTIF: N-glycosylation site {N496}
immunoglobulin superfamily domain {573-631}
MOTIF: cysteine residue {C580}
MODIFICATION: cysteine residue {C624}
N-glycosylation site {N607}
cysteine residue {C624}
MODIFICATION: cysteine residue {C580}
transmembrane domain {684-704}
Thr phosphorylation site {T744}
Ser phosphorylation site {S747}
Database Correlations
OMIM correlations
MORBIDMAP 607292
UniProt Q9H3S1
PFAM correlations
Entrez Gene 64218
Kegg hsa:64218
References
- UniProt :accession Q9H3S1
- Entrez Gene :accession 10510