Search
semaphorin-3F; semaphorin IV; sema IV; sema III/F (SEMA3F)
Function:
- may play a role in cell motility & cell adhesion
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 sema domain
Compartment:
- secreted (putative)
Expression:
- expressed abundantly but differentially in a variety of neural & nonneural tissues
- high expression in mammary gland, kidney, fetal brain, & lung
- lower expression in heart & liver
- detected as early as embryonic day 10
General
glycoprotein
secreted protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 785 aa
MW = 88 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
Sema {31-545}
MOTIF: N-glycosylation site {N53}
cysteine residue {C104}
MODIFICATION: cysteine residue {C115}
cysteine residue {C115}
MODIFICATION: cysteine residue {C104}
N-glycosylation site {N126}
cysteine residue {C133}
MODIFICATION: cysteine residue {C142}
cysteine residue {C142}
MODIFICATION: cysteine residue {C133}
cysteine residue {C300}
MODIFICATION: cysteine residue {C412}
cysteine residue {C324}
MODIFICATION: cysteine residue {C372}
cysteine residue {C372}
MODIFICATION: cysteine residue {C324}
cysteine residue {C412}
MODIFICATION: cysteine residue {C300}
immunoglobulin superfamily domain {605-690}
MOTIF: cysteine residue {C678}
MODIFICATION: cysteine residue {C746}
cysteine residue {C746}
MODIFICATION: cysteine residue {C678}
lysine-rich region {758-779}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM 601124
UniProt Q13275
Pfam PF01403
Entrez Gene 6405
Kegg hsa:6405
References
- UniProt :accession Q13275
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/SEMA3FID42254ch3p21.html
- Entrez Gene :accession 6405