semaphorin-3D (SEMA3D)

Function: - induces the collapse & paralysis of neuronal growth cones - may act as repulsive cues toward specific neuronal populations - binds to neuropilin (putative) Structure: - strong binding to neuropilin is mediated by the C-terminal 3rd of the protein - belongs to the semaphorin family - contains 1 Ig-like C2-type domain (immunoglobulin-like) - contains 1 PSI domain - contains 1 sema domain Compartment: - secreted (putative)

General

glycoprotein secreted protein semaphorin or semaphorin/collapsin family protein

Properties

SIZE: entity length = 777 aa MW = 90 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-36} Sema {44-531} MOTIF: cysteine residue {C117} MODIFICATION: cysteine residue {C128} cysteine residue {C128} MODIFICATION: cysteine residue {C117} N-glycosylation site {N139} cysteine residue {C146} MODIFICATION: cysteine residue {C155} cysteine residue {C155} MODIFICATION: cysteine residue {C146} cysteine residue {C286} MODIFICATION: cysteine residue {C398} cysteine residue {C310} MODIFICATION: cysteine residue {C358} cysteine residue {C358} MODIFICATION: cysteine residue {C310} cysteine residue {C398} MODIFICATION: cysteine residue {C286} PSI {533-585} immunoglobulin superfamily domain {592-680} MOTIF: N-glycosylation site {N607} cysteine residue {C665} MODIFICATION: cysteine residue {C731} N-glycosylation site {N724} cysteine residue {C731} MODIFICATION: cysteine residue {C665} lysine-rich region {739-773} MOTIF: lysine residue (SEVERAL)

Database Correlations

OMIM 609907 UniProt O95025 PFAM correlations Entrez Gene 223117 Kegg hsa:223117