Search
semaphorin-3C; semaphorin-E; sema E (SEMA3C SEMAE)
Function:
- may be involved in diverse cell survival mechanisms
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- secreted
Expression:
- expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, & prostate
- faint expression ubiquitously among other organs, including brain
General
glycoprotein
secreted protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 751 aa
MW = 85 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
Sema {28-511}
MOTIF: N-glycosylation site {N81}
cysteine residue {C101}
MODIFICATION: cysteine residue {C112}
cysteine residue {C112}
MODIFICATION: cysteine residue {C101}
N-glycosylation site {N123}
cysteine residue {C130}
MODIFICATION: cysteine residue {C139}
cysteine residue {C139}
MODIFICATION: cysteine residue {C130}
N-glycosylation site {N252}
cysteine residue {C266}
MODIFICATION: cysteine residue {C378}
N-glycosylation site {N268}
cysteine residue {C290}
MODIFICATION: cysteine residue {C338}
cysteine residue {C338}
MODIFICATION: cysteine residue {C290}
cysteine residue {C378}
MODIFICATION: cysteine residue {C266}
N-glycosylation site {N465}
immunoglobulin superfamily domain {571-655}
MOTIF: N-glycosylation site {N585}
N-glycosylation site {N586}
cysteine residue {C643}
MODIFICATION: cysteine residue {C709}
cysteine residue {C709}
MODIFICATION: cysteine residue {C643}
lysine-rich region {724-745}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM 602645
UniProt Q99985
Pfam PF01403
Entrez Gene 10512
Kegg hsa:10512
References
- UniProt :accession Q99985
- Entrez Gene :accession 10512