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semaphorin 3B, semaphorin V or semaphorin A
Function:
- inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons
Structure:
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment:
- secreted (putative)
- endoplasmic reticulum
- accumulates in the endoplasmic reticulum
Alternative splicing:
- named isoforms=2
Expression:
- expressed abundantly but differentially in a variety of neural & nonneural tissues
General
glycoprotein
secreted protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 749 aa
MW = 83 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-24}
Sema {30-513}
MOTIF: N-glycosylation site {N82}
cysteine residue {C102}
MODIFICATION: cysteine residue {C113}
cysteine residue {C113}
MODIFICATION: cysteine residue {C102}
N-glycosylation site {N124}
cysteine residue {C131}
MODIFICATION: cysteine residue {C140}
cysteine residue {C140}
MODIFICATION: cysteine residue {C131}
cysteine residue {C269}
MODIFICATION: cysteine residue {C380}
cysteine residue {C293}
MODIFICATION: cysteine residue {C340}
cysteine residue {C340}
MODIFICATION: cysteine residue {C293}
cysteine residue {C380}
MODIFICATION: cysteine residue {C269}
N-glycosylation site {N427}
immunoglobulin superfamily domain {573-659}
MOTIF: cysteine residue {C644}
MODIFICATION: cysteine residue {C710}
glycine-rich region {699-702}
cysteine residue {C710}
MODIFICATION: cysteine residue {C644}
arginine-rich region {724-744}
MOTIF: arginine residue (SEVERAL)
Database Correlations
OMIM 601281
UniProt Q13214
PFAM correlations
Entrez Gene 7869
Kegg hsa:7869
References
- UniProt :accession Q13214
- Entrez Gene :accession 7869