Search
semaphorin-3A; semaphorin III; sema III (SEMA3A SEMAD)
Function:
- induces the collapse & paralysis of neuronal growth cones
- may serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism
- binds to the complex neuropilin-1/plexin-1 (putative)
- in mice, simultaneously promotes bone formation & inhibits bone resorption [3]
Structure:
- strong binding to neuropilin is mediated by the C-terminal 3rd of the protein
- belongs to the semaphorin family
- contains 1 Ig-like C2-type domain (immunoglobulin-like)
- contains 1 PSI domain
- contains 1 sema domain
Compartment: secreted (putative)
General
glycoprotein
secreted protein
semaphorin or semaphorin/collapsin family protein
Properties
SIZE: entity length = 771 aa
MW = 89 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
Sema {31-514}
MOTIF: N-glycosylation site {N53}
cysteine residue {C103}
MODIFICATION: cysteine residue {C114}
cysteine residue {C114}
MODIFICATION: cysteine residue {C103}
N-glycosylation site {N125}
cysteine residue {C132}
MODIFICATION: cysteine residue {C141}
cysteine residue {C141}
MODIFICATION: cysteine residue {C132}
cysteine residue {C269}
MODIFICATION: cysteine residue {C381}
cysteine residue {C293}
MODIFICATION: cysteine residue {C341}
cysteine residue {C341}
MODIFICATION: cysteine residue {C293}
cysteine residue {C381}
MODIFICATION: cysteine residue {C269}
immunoglobulin superfamily domain {580-664}
MOTIF: N-glycosylation site {N590}
cysteine residue {C649}
MODIFICATION: cysteine residue {C722}
cysteine residue {C722}
MODIFICATION: cysteine residue {C649}
lysine-rich region {727-769}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM 603961
UniProt Q14563
Pfam PF01403
Entrez Gene 10371
Kegg hsa:10371
References
- UniProt :accession Q14563
- Entrez Gene :accession 10371
- Hayashi M et al.
Osteoprotection by semaphorin 3A.
Nature 2012 May 3; 485:69
PMID: 22522930
- Zaidi M and Iqbal J.
Double protection for weakened bones.
Nature 2012 May 3; 485:47
PMID: 22552091