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protein sel-1 homolog 1; suppressor of lin-12-like protein 1; sel-1L (SEL1L, TSA305, UNQ128/PRO1063)
Function:
- probable role in notch signaling
- may play role in endoplasmic reticulum quality control (ERQC) (ER-associated degradation, ERAD)
- involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins
- part of a complex containing SEL1L, SYVN1 & DERL2
- may form a complex with ERLEC1, HSPA5, OS9, & SYVN1
- interacts with FOXRED2
Structure:
- N-glycosylated
- belongs to the sel-1 family
- contains 1 fibronectin type-II domain
- contains 11 sel1-like repeats
Compartment:
- endoplasmic reticulum membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
Expression: highly expressed in pancreas
General
glycoprotein
membrane protein
Properties
SIZE: entity length = 794 aa
MW = 89 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-21}
ERLEC1, OS9 & SYVN1 interaction {22-737}
MOTIF: fibronectin type II domain or F2 module
SITE: 122-170
FOR-BINDING-OF: collagen
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*3}
cysteine residue {*2}
MODIFICATION: cysteine residue {*4}
cysteine residue {*3}
MODIFICATION: cysteine residue {*1}
cysteine residue {*4}
MODIFICATION: cysteine residue {*2}
cysteine residue {C127}
MODIFICATION: cysteine residue {C153}
cysteine residue {C141}
MODIFICATION: cysteine residue {C168}
cysteine residue {C153}
MODIFICATION: cysteine residue {C127}
cysteine residue {C168}
MODIFICATION: cysteine residue {C141}
Sel1-like {183-218}
N-glycosylation site {N195}
N-glycosylation site {N217}
Sel1-like {219-254}
Sel1-like {255-290}
N-glycosylation site {N272}
Sel1-like {291-326}
Sel1-like {373-409}
Sel1-like {410-446}
N-glycosylation site {N431}
Sel1-like {447-482}
Sel1-like {483-518}
Sel1-like {519-554}
N-glycosylation site {N608}
Sel1-like {627-662}
Sel1-like {664-699}
ER retention {738-794}
MOTIF: transmembrane domain {739-759}
proline-rich region
SITE: 770-793
MOTIF: proline residue (SEVERAL)
Database Correlations
OMIM 602329
UniProt Q9UBV2
PFAM correlations
Entrez Gene 6400
Kegg hsa:6400
References
- UniProt :accession Q9UBV2
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/SEL1LID42246ch14q24.html