selenoprotein P; SeP (SEPP1 SELP)

Function: - might be responsible for some extracellular antioxidant defense properties of selenium - might be involved in transport of selenium - may supply selenium to tissues such as brain & testis - phosphorylation sites are present in the extracellular medium Structure: belongs to the selenoprotein P family Compartment: secreted Expression: -made in the liver & heart & secreted into the plasma - also found in the kidney

General

glycoprotein phosphoprotein secreted protein selenoprotein

Properties

SIZE: entity length = 381 aa MW = 43 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-19} N-glycosylation site {N46} selenocysteine residue {C59} N-glycosylation site {N83} N-glycosylation site {N119} N-glycosylation site {N128} N-glycosylation site {N174} histidine-rich region {244-249} MOTIF: histidine residue (SEVERAL) Ser phosphorylation site {S266} selenocysteine residue {C300} selenocysteine residue {C318} selenocysteine residue {C330} N-glycosylation site {N338} selenocysteine residue {C345} selenocysteine residue {C352} selenocysteine residue {C367} selenocysteine residue {C369} selenocysteine residue {C376} selenocysteine residue {C378}

Database Correlations

OMIM 601484 UniProt P49908 PFAM correlations Entrez Gene 6414 Kegg hsa:6414