selenide, water dikinase 1; selenium donor protein 1; selenophosphate synthase 1 (SEPHS1, SELD SPS, SPS1)

Function: - synthesizes selenophosphate from selenide & ATP - activated by phosphate & by K⁺ ATP + selenide + H₂O = AMP + selenophosphate + phosphate Structure: - homodimer - belongs to the selenophosphate synthase 1 family class II subfamily - the conserved active site Cys (or selenocysteine) residue in position 29 is replaced by a Thr; however, as function in selenoprotein synthesis is proven, it is possible Cys-31 is the active site

Properties

SIZE: entity length = 392 aa MW = 43 kD MOTIF: cysteine residue {C31} ATP-binding site NAME: ATP-binding site SITE: 32-32 MOTIF: lysine residue {32} ATP-binding site NAME: ATP-binding site SITE: 67-69 ATP-binding site NAME: ATP-binding site SITE: 87-87 ATP-binding site NAME: ATP-binding site SITE: 110-110 ATP-binding site NAME: ATP-binding site SITE: 162-164 ATP-binding site NAME: ATP-binding site SITE: 267-273 Ser phosphorylation site {S392}

Database Correlations

OMIM 600902 UniProt P49903 PFAM correlations Entrez Gene 22929 Kegg hsa:22929 ENZYME 2.7.9.3

References

UniProt :accession P49903