selenium-binding protein 1; 56 kD selenium-binding protein; SBP56; SP56 (SELENBP1 SBP)

Function: - selenium-binding protein - may be involved in sensing of reactive xenobiotics in the cytoplasm - may be involved in intra-Golgi protein transport - phosphorylated (probable) - interacts with USP33 Structure: - the N-terminus is blocked (putative) - belongs to the selenium-binding protein family Compartment: - nucleus, cytoplasm, cytosol, membrane - peripheral membrane protein (putative) - may associate with Golgi membrane - may associate with the membrane of autophagosomes Alternative splicing: named isoforms=2 Expression: - highly expressed in liver, lung, colon, prostate, kidney & pancreas - expressed in brain, both in neurons & glia (at protein level) - down-regulated in lung adenocarcinoma, colorectal carcinoma & ovarian cancer - two-fold up-regulated in brain & blood from patients with schizophrenia - expression down-regulated by androgen in prostate cancer cells

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 472 aa MW = 52 kD COMPARTMENT: cytoplasm cell nucleus golgi MOTIF: Ser phosphorylation site {S467}

Database Correlations

OMIM 604188 UniProt Q13228 Pfam PF05694 Entrez Gene 8991 Kegg hsa:8991

References

UniProt :accession Q13228