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RNA polymerase 1 promoter selectivity factor SL1
Function:
- SL1 is responsible for species specificity of rRNA transcription
Structure:
- 4 subunits
- TBP
- since the promoter for ribosomal RNA genes does not contain a TATA box, TBP does not bind to specific promoter sequences
- instead, the association of TBP with ribosomal RNA genes is mediated by the binding of other proteins in the SL1 complex to the promoter, a situation similar to the association of TBP with the Inr sequences of polymerase 2 genes that lack TATA boxes
Interactions
molecular events
General
DNA-binding protein
molecular complex
transcription factor (TF)
Properties
COMPARTMENT: nucleolus
MOTIF: DNA-binding motif
SUBUNITS: TATA-box-binding protein
COMPARTMENT: cell nucleus
MOTIF: glutamine-rich region {55-95}
MOTIF: glutamine residue (SEVERAL)
consensus repeat {165-241}
consensus repeat {255-332}
MISC-INFO: COPIES 100-400 MOLECULES/CELL
References
- Bell et al Science 241:1192 1988
- Dynlacht BD.
Retinoblastoma protein. Pol I gets repressed.
Nature. 1995 Mar 9;374(6518):114. No abstract available.
PMID: 7877677
Component-of
molecular complex
Components
TATA-box-binding protein; TATA sequence-binding protein; TATA-binding factor; TATA-box factor; transcription initiation factor TFIID TBP subunit; p38TFIID; p38tau (TBP, GTF2D1, TF2D, TFIID)