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selection & upkeep of intraepithelial T-cells protein 1 homolog (SKINT1)
Structure:
- belongs to the SKINT family
- contains 1 Ig-like C1-type domain (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: membrane (putative)
Comparative biology:
- compared to the mouse protein family, it is shorter at the N-terminus & C-terminus due to premature stop codons, suggesting it is inactive [1]
Notes:
- removed from UniProt KB 2016
- could be the product of a pseudogene
General
glycoprotein
membrane protein
Properties
SIZE: entity length = 218 aa
MW = 25 kD
COMPARTMENT: cellular membrane
MOTIF: immunoglobulin superfamily domain {1-82}
MOTIF: N-glycosylation site {N53}
immunoglobulin superfamily domain {83-174}
MOTIF: cysteine residue {C104}
MODIFICATION: cysteine residue {C158}
N-glycosylation site {N155}
cysteine residue {C158}
MODIFICATION: cysteine residue {C104}
transmembrane domain {184-204}
Database Correlations
PFAM correlations
References
- Boyden LM et al
Skint1, the prototype of a newly identified immunoglobulin
superfamily gene cluster, positively selects epidermal gamma-
delta T cells.
Nat Genet. 2008 May;40(5):656-62. Epub 2008 Apr 13.
PMID: 18408721