seizure protein 6 homolog (SEZ-6, hSEZ-6, SEZ6)

Function: - may play a role in cell-cell recognition & in neuronal membrane signaling - role in balance between dendrite elongation & branching during the elaboration of a complex dendritic arbor (putative) - role in development of appropriate excitatory synaptic connectivity Structure: - glycosylated (putative) - belongs to the SEZ6 family - contains 2 CUB domains - contains 5 Sushi (CCP/SCR) domains Compartment: - cell membrane; (putative) - localized on dendrites & in the synaptic & postsynaptic fraction (putative) Alternative splicing: named isoforms=4 Pathology: - genetic variations in SEZ6 may be involved in susceptibility to febrile convulsion

General

glycoprotein membrane protein phosphoprotein

Properties

SIZE: entity length = 994 aa MW = 107 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-19} proline-rich region SITE: 90-188 MOTIF: proline residue (SEVERAL) threonine-rich region {211-240} MOTIF: threonine residue (SEVERAL) N-glycosylation site {N289} Sushi domain {355-414} MOTIF: cysteine residue {C357} MODIFICATION: cysteine residue {C397} Tyr phosphorylation site {Y365} cysteine residue {C383} MODIFICATION: cysteine residue {C412} Tyr phosphorylation site {Y387} cysteine residue {C397} MODIFICATION: cysteine residue {C357} N-glycosylation site {N399} cysteine residue {C412} MODIFICATION: cysteine residue {C383} CUB domain {416-527} MOTIF: cysteine residue {C416} MODIFICATION: cysteine residue {C443} N-glycosylation site {N436} cysteine residue {C443} MODIFICATION: cysteine residue {C416} Sushi domain {530-591} MOTIF: cysteine residue {C532} MODIFICATION: cysteine residue {C574} N-glycosylation site {N541} cysteine residue {C559} MODIFICATION: cysteine residue {C589} cysteine residue {C574} MODIFICATION: cysteine residue {C532} cysteine residue {C589} MODIFICATION: cysteine residue {C559} CUB domain {593-704} MOTIF: cysteine residue {C593} MODIFICATION: cysteine residue {C619} cysteine residue {C619} MODIFICATION: cysteine residue {C593} Sushi domain {708-767} MOTIF: cysteine residue {C710} MODIFICATION: cysteine residue {C752} cysteine residue {C738} MODIFICATION: cysteine residue {C765} cysteine residue {C752} MODIFICATION: cysteine residue {C710} cysteine residue {C765} MODIFICATION: cysteine residue {C738} Sushi domain {769-832} MOTIF: cysteine residue {C771} MODIFICATION: cysteine residue {C813} cysteine residue {C799} MODIFICATION: cysteine residue {C830} cysteine residue {C813} MODIFICATION: cysteine residue {C771} cysteine residue {C830} MODIFICATION: cysteine residue {C799} Sushi domain {836-897} MOTIF: cysteine residue {C838} MODIFICATION: cysteine residue {C880} cysteine residue {C866} MODIFICATION: cysteine residue {C895} cysteine residue {C880} MODIFICATION: cysteine residue {C838} cysteine residue {C895} MODIFICATION: cysteine residue {C866} transmembrane domain {926-946}

Database Correlations

UniProt Q53EL9 PFAM correlations

References

UniProt :accession Q53EL9