Seizure 6-like protein 2 (SEZ6L2 PSK UNQ1903/PRO4349)

Function: - may contribuates to specialized endoplasmic reticulum functions in neurons Structure: - belongs to the SEZ6 family - contains 3 CUB domains - contains 5 Sushi (CCP/SCR) domains Compartment: - cell membrane, endoplasmic reticulum membrane Alternative splicing: named isoforms=4 Pathology: - detected on cell surface in lung-cancers - increased expression in the majority of primary lung cancers & lung-cell lines tested - may serve as a prognostic marker for lung cancers

General

glycoprotein membrane protein

Properties

SIZE: entity length = 910 aa MW = 98 kD COMPARTMENT: plasma membrane endoplasmic reticulum MOTIF: signal sequence {1-27} proline-rich region SITE: 70-146 MOTIF: proline residue (SEVERAL) threonine-rich region {153-168} MOTIF: threonine residue (SEVERAL) CUB domain {173-286} MOTIF: cysteine residue {C173} MODIFICATION: cysteine residue {C202} N-glycosylation site {N176} cysteine residue {C202} MODIFICATION: cysteine residue {C173} N-glycosylation site {N222} N-glycosylation site {N247} Sushi domain {288-347} MOTIF: cysteine residue {C290} MODIFICATION: cysteine residue {C330} cysteine residue {C316} MODIFICATION: cysteine residue {C345} cysteine residue {C330} MODIFICATION: cysteine residue {C290} N-glycosylation site {N332} cysteine residue {C345} MODIFICATION: cysteine residue {C316} CUB domain {349-459} MOTIF: cysteine residue {C349} MODIFICATION: cysteine residue {C376} N-glycosylation site {N355} N-glycosylation site {N373} cysteine residue {C376} MODIFICATION: cysteine residue {C349} Sushi domain {462-525} MOTIF: cysteine residue {C464} MODIFICATION: cysteine residue {C508} N-glycosylation site {N473} cysteine residue {C491} MODIFICATION: cysteine residue {C523} cysteine residue {C508} MODIFICATION: cysteine residue {C464} N-glycosylation site {N517} cysteine residue {C523} MODIFICATION: cysteine residue {C491} CUB domain {527-638} MOTIF: cysteine residue {C527} MODIFICATION: cysteine residue {C553} cysteine residue {C553} MODIFICATION: cysteine residue {C527} N-glycosylation site {N641} Sushi domain {642-701} MOTIF: cysteine residue {C644} MODIFICATION: cysteine residue {C686} cysteine residue {C672} MODIFICATION: cysteine residue {C699} cysteine residue {C686} MODIFICATION: cysteine residue {C644} cysteine residue {C699} MODIFICATION: cysteine residue {C672} Sushi domain {703-766} MOTIF: cysteine residue {C705} MODIFICATION: cysteine residue {C747} cysteine residue {C733} MODIFICATION: cysteine residue {C764} cysteine residue {C747} MODIFICATION: cysteine residue {C705} cysteine residue {C764} MODIFICATION: cysteine residue {C733} Sushi domain {769-830} MOTIF: cysteine residue {C771} MODIFICATION: cysteine residue {C813} cysteine residue {C799} MODIFICATION: cysteine residue {C828} cysteine residue {C813} MODIFICATION: cysteine residue {C771} cysteine residue {C828} MODIFICATION: cysteine residue {C799} transmembrane domain {845-865}

Database Correlations

UniProt Q6UXD5 PFAM correlations

References

UniProt :accession Q6UXD5