seizure 6-like protein (SEZ6L KIAA0927 UNQ2542/PRO6094)

Function: - tumor suppressor ? Structure: - contains 3 CUB domains - contains 5 Sushi domains (CCP/SCR domains) Compartment: membrane Alternative splicing: named isoforms=5 Expression: - widely expressed, including adult & fetal brain & lungs Pathology: 1) not expressed in all lung cancer cell lines 2) SEZ6L gene is located in a 22q region, which is frequently deleted in small cell lung carcinomas (SCLCs) & advanced non-small cell lung carcinomas

General

glycoprotein membrane protein

Properties

SIZE: MW = 112 kD entity length = 1024 aa COMPARTMENT: cellular membrane MOTIF: signal sequence {1-28} CUB domain {281-389} MOTIF: cysteine residue {C281} MODIFICATION: cysteine residue {C308} cysteine residue {C308} MODIFICATION: cysteine residue {C281} N-glycosylation site {N311} N-glycosylation site {N328} N-glycosylation site {N350} Sushi domain {391-450} MOTIF: cysteine residue {C393} MODIFICATION: cysteine residue {C433} cysteine residue {C419} MODIFICATION: cysteine residue {C448} cysteine residue {C433} MODIFICATION: cysteine residue {C393} N-glycosylation site {N435} cysteine residue {C448} MODIFICATION: cysteine residue {C419} CUB domain {452-562} MOTIF: N-glycosylation site {N458} N-glycosylation site {N474} N-glycosylation site {N514} Sushi domain {565-626} MOTIF: cysteine residue {C567} MODIFICATION: cysteine residue {C609} N-glycosylation site {N576} cysteine residue {C594} MODIFICATION: cysteine residue {C624} cysteine residue {C609} MODIFICATION: cysteine residue {C567} N-glycosylation site {N618} cysteine residue {C624} MODIFICATION: cysteine residue {C594} CUB domain {628-739} MOTIF: N-glycosylation site {N674} N-glycosylation site {N742} Sushi domain {743-802} MOTIF: cysteine residue {C745} MODIFICATION: cysteine residue {C787} cysteine residue {C773} MODIFICATION: cysteine residue {C800} cysteine residue {C787} MODIFICATION: cysteine residue {C745} cysteine residue {C800} MODIFICATION: cysteine residue {C773} Sushi domain {804-867} MOTIF: cysteine residue {C806} MODIFICATION: cysteine residue {C848} cysteine residue {C834} MODIFICATION: cysteine residue {C865} cysteine residue {C848} MODIFICATION: cysteine residue {C806} cysteine residue {C865} MODIFICATION: cysteine residue {C834} Sushi domain {871-932} MOTIF: cysteine residue {C873} MODIFICATION: cysteine residue {C915} cysteine residue {C901} MODIFICATION: cysteine residue {C930} cysteine residue {C915} MODIFICATION: cysteine residue {C873} cysteine residue {C930} MODIFICATION: cysteine residue {C901} transmembrane domain {959-979}

Database Correlations

OMIM 607021 UniProt Q9BYH1 PFAM correlations

References

UniProt :accession Q9BYH1