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prolactin-inducible protein; gross cystic disease fluid protein 15; GCDFP-15; prolactin-induced protein; secretory actin-binding protein; SABP; gp17 (PIP, GCDFP15, GPIP4, BRST-2)
Function:
- interacts with AZGP1
Structure:
- monomer
- belongs to the PIP family
Compartment: secreted
Expression:
- induced by prolactin & androgen
- inhibited by estrogen
- expressed in pathological conditions of the mammary gland
- expressed in several exocrine tissues, such as the lacrimal gland, salivary gland, & sweat glands
Laboratory:
- BRST-2 Ag in tissue
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 146 aa
MW = 17 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-28}
cysteine residue {C65}
MODIFICATION: cysteine residue {C91}
cysteine residue {C89}
MODIFICATION: cysteine residue {C123}
cysteine residue {C91}
MODIFICATION: cysteine residue {C65}
N-glycosylation site {N105}
cysteine residue {C123}
MODIFICATION: cysteine residue {C89}
Database Correlations
OMIM 176720
UniProt P12273
Pfam PF05326
Entrez Gene 5304
Kegg hsa:5304
References
UniProt :accession P12273