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neuroendocrine protein 7B2; pituitary polypeptide; secretogranin V; secretogranin-5; secretory granule endocrine protein I; contains: N-terminal peptide; C-terminal peptide (SCG5, SGNE1)
Function:
- acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway
- binds to inactive PCSK2 in the endoplasmic reticulum & facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured & activated
- also required for cleavage of PCSK2 but does not appear to be involved in its folding
- role in regulating pituitary hormone secretion
- the C-terminal peptide inhibits PCSK2 in vitro
- proteolytically cleaved in the Golgi by a furin-like convertase to generate bioactive peptides (putative)
- sulfated on Tyr (putative)
- interacts with PCSK2/PC2 early in the secretory pathway
- dissociation occurs at later stages
Structure: belongs to the 7B2 family
Compartment:
- secreted
- neuroendocrine & endocrine secretory granules
Alternative splicing: named isoforms=2
Related
SGNE1 (secretogranin V gene)
General
chromogranin; secretogranin;granin
Properties
SIZE: entity length = 212 aa
MW = 24 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
cysteine residue {C120}
MODIFICATION: cysteine residue {C130}
cysteine residue {C130}
MODIFICATION: cysteine residue {C120}
Ser phosphorylation site {S205}
MISC-INFO: ISOELECTIC_POINT 5.2
Database Correlations
OMIM 173120
UniProt P05408
Pfam PF05281
Entrez Gene 6447
Kegg hsa:6447
References
- UniProt :accession P05408
- Huttner WB, Gerdes HH, Rosa P.
The granin (chromogranin/secretogranin) family.
Trends Biochem Sci. 1991 Jan;16(1):27-30. Review.
PMID: 2053134