Search
secretogranin-2; chromogranin-C; secretogranin II; SgII; contains: secretoneurin; SN (SCG2, CHGC)
Function:
- neuroendocrine secretory granule protein
- precursor for biologically active peptides
Structure:
- belongs to the chromogranin/secretogranin protein family
Compartment:
- secreted
- neuroendocrine & endocrine secretory granules
Notes:
- binds Ca+2 with a low-affinity
General
chromogranin; secretogranin;granin
phosphoprotein
Properties
SIZE: entity length = 617 aa
MW = 71 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-27}
Ser phosphorylation site {S532}
Ser phosphorylation site {S533}
MISC-INFO: ISOELECTIC_POINT 5.0
Database Correlations
OMIM 118930
UniProt P13521
Pfam PF01271
Entrez Gene 7857
Kegg hsa:7857
References
- UniProt :accession P13521
- Huttner WB, Gerdes HH, Rosa P.
The granin (chromogranin/secretogranin) family.
Trends Biochem Sci. 1991 Jan;16(1):27-30. Review.
PMID: 2053134