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secretion-regulating guanine nucleotide exchange factor (guanine nucleotide exchange factor-related protein, deafness locus-associated putative guanine nucleotide exchange factor, DelGEF, SERGEF, DELGEF, GNEFR)
Function:
- probable guanine nucleotide exchange factor
- may be involved in secretion
- interaction with SEC5 (Mg+2 or Mn+2 dependent) stimulated by dCTP or GTP
Structure:
- contains 7 RCC1 repeats
Compartment: cytoplasm, nucleus
Alternative splicing: named isoforms=2
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
SIZE: MW = 49 kD
entity length = 458 aa
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: RCC1 repeat {15-67}
RCC1 repeat {68-119}
RCC1 repeat {120-171}
RCC1 repeat {172-230}
RCC1 repeat {231-283}
RCC1 repeat {284-351}
RCC1 repeat {352-402}
Database Correlations
OMIM 606051
UniProt Q9UGK8
Pfam PF00415
References
UniProt :accession Q9UGK8