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secreted Ly-6/uPAR-related protein 1; SLURP-1; ARS component B; ARS(component B)-81/S; anti-neoplastic urinary protein; ANUP (SLURP1 ARS)
Function:
- has antineoplastic activity
- found to be a marker of late differentiation of the skin
- implicated in maintaining the physiological & structural integrity of the keratinocyte layers of the skin
Structure:
- homodimer
- contains 1 UPAR/Ly6 domain
Compartment: secreted
Expression:
- expressed granulocytes.
- expressed in skin
- predominantly expressed in the granular layer of skin, notably the acrosyringium
- identified in sweat, saliva, tears, plasma & urine
- regulated by retinoic acid, EGF & IFN-gamma
Pathology:
- mutations associated with Meleda disease
General
secreted protein
Properties
SIZE: entity length = 103 aa
MW = 11 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
UPAR/Ly6 {24-73}
MOTIF: cysteine residue {C25}
MODIFICATION: cysteine residue {C50}
cysteine residue {C28}
MODIFICATION: cysteine residue {C37}
cysteine residue {C37}
MODIFICATION: cysteine residue {C28}
cysteine residue {C43}
MODIFICATION: cysteine residue {C73}
cysteine residue {C50}
MODIFICATION: cysteine residue {C25}
cysteine residue {C73}
MODIFICATION: cysteine residue {C43}
cysteine residue {C77}
MODIFICATION: cysteine residue {C93}
cysteine residue {C93}
MODIFICATION: cysteine residue {C77}
cysteine residue {C94}
MODIFICATION: cysteine residue {C99}
cysteine residue {C99}
MODIFICATION: cysteine residue {C94}
Database Correlations
OMIM correlations
MORBIDMAP 606119
UniProt P55000
Pfam PF00021
Entrez Gene 57152
Kegg hsa:57152
References
UniProt :accession P55000