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secreted Ly-6/uPAR domain-containing protein 2; secreted LY6/PLAUR domain-containing protein 2; secreted Ly-6/uPAR-related protein 2; SLURP-2 (SLURP2)
Function:
- binds & may modulate function of acetylcholine receptors,
- nicotinic receptors & muscarinic receptors
- may regulate keratinocyte proliferation, differentiation & apoptosis
- in vitro moderately inhibits ACh-evoked currents of alpha-3:beta-2- containing nAChRs & strongly these of alpha-4: beta-2-containing nAChRs
- modulates alpha-7-containing nAChRs, & inhibits nicotine- induced signaling probably implicating alpha-3:beta-4- containing nAChRs
- proposed to act on alpha-3:beta-2 & alpha-7 nAChRs in an orthosteric, & on mAChRs, such as CHRM1 & CHRM3, in an allosteric manner
- interacts with CHRNA3, CHRNA4, CHRNA5, CHRNA7, CHRNB2 & CHRNB4
- interacts with CHRM1 & CHRM3 probably in an allosteric manner
Compartment: secreted
Expression:
- expressed cervix & esophagus > adult & fetal skin > brain, lung, stomach, small intestine, colon, rectum, uterus, & thymus
- not detected in spleen or bone marrow
- in the epidermis, predominantly produced by keratinocytes of the suprabasal epidermal compartment (at protein level)
- in attached gingiva, produced at highest levels by basal cells located in the lowermost epithelial layers (at protein level)
- detected in serum (at protein level)
- up-regulation by IL-22 is suppressed by IFN-gamma (at protein level)
Pathology:
- expression is up-regulated 3-fold in psoriatic lesional skin
General
secreted protein
Properties
SIZE: entity length = 97 aa
MW = 10 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-22}
UPAR/Ly6. {25-95}
MOTIF: cysteine residue {C25}
MODIFICATION: cysteine residue {C47}
cysteine residue {C28}
MODIFICATION: cysteine residue {C34}
cysteine residue {C34}
MODIFICATION: cysteine residue {C28}
cysteine residue {C40}
MODIFICATION: cysteine residue {C68}
cysteine residue {C47}
MODIFICATION: cysteine residue {C25}
cysteine residue {C68}
MODIFICATION: cysteine residue {C40}
cysteine residue {C72}
MODIFICATION: cysteine residue {C88}
cysteine residue {C88}
MODIFICATION: cysteine residue {C72}
cysteine residue {C89}
MODIFICATION: cysteine residue {C94}
cysteine residue {C94}
MODIFICATION: cysteine residue {C89}
Database Correlations
OMIM 606110
UniProt P0DP57
Pfam PF00021
Entrez Gene 66004
Kegg hsa:66004
References
- UniProt :accession P0DP57
- PubMed refs
- PMID: 27485575
- PMID: 16575903