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secreted frizzled-related protein 5; sFRP-5; Frizzled-related protein 1b; FRP-1b; secreted apoptosis-related protein 3; SARP-3 (SFRP5, FRP1B, SARP3)
Function:
- soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts
- they have a role in regulating cell growth & differentiation in specific cell types
- SFRP5 may be involved in determining the polarity of photoreceptors, & perhaps, other cells in the retina
Structure:
- the FZ domain is involved in binding with Wnt ligands
- belongs to the secreted frizzled-related protein (sFRP) family
- contains 1 FZ (frizzled) domain
- contains 1 NTR domain
Compartment: secreted (putative)
Expression:
- highly expressed in the retinal pigment epithelium (RPE) & pancreas
- weak expression in heart, liver & muscle
General
apoptosis related protein
secreted frizzled-related protein (sFRP) family
Properties
SIZE: entity length = 317 aa
MW = 36 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-29}
frizzled domain {48-165}
MOTIF: cysteine residue {C53}
MODIFICATION: cysteine residue {C116}
cysteine residue {C63}
MODIFICATION: cysteine residue {C109}
cysteine residue {C100}
MODIFICATION: cysteine residue {C135}
cysteine residue {C109}
MODIFICATION: cysteine residue {C63}
cysteine residue {C116}
MODIFICATION: cysteine residue {C53}
cysteine residue {C124}
MODIFICATION: cysteine residue {C162}
cysteine residue {C128}
MODIFICATION: cysteine residue {C152}
cysteine residue {C135}
MODIFICATION: cysteine residue {C100}
cysteine residue {C152}
MODIFICATION: cysteine residue {C128}
cysteine residue {C162}
MODIFICATION: cysteine residue {C124}
NTR {181-303}
MOTIF: cysteine residue {C181}
MODIFICATION: cysteine residue {C253}
cysteine residue {C184}
MODIFICATION: cysteine residue {C255}
cysteine residue {C198}
MODIFICATION: cysteine residue {C303}
cysteine residue {C253}
MODIFICATION: cysteine residue {C181}
cysteine residue {C255}
MODIFICATION: cysteine residue {C184}
cysteine residue {C303}
MODIFICATION: cysteine residue {C198}
Database Correlations
OMIM 604158
UniProt Q5T4F7
PFAM correlations
Entrez Gene 6425
Kegg hsa:6425
References
UniProt :accession Q5T4F7