Search
secreted frizzled-related protein 2; FRP-2; sFRP-2; secreted apoptosis-related protein 1; SARP-1 (SFRP2, FRP2, SARP1, FKSG12, UNQ361/PRO697)
Function:
- soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts
- they have a role in regulating cell growth & differentiation in specific cell types
- SFRP2 may be important for eye retinal development & for myogenesis
Structure:
- the FZ domain is involved in binding with Wnt ligands
- belongs to the secreted frizzled-related protein (sFRP) family
- contains 1 FZ (frizzled) domain
- contains 1 NTR domain
Compartment: secreted (putative)
Expression:
- expressed in adipose tissue, heart, brain, skeletal muscle, pancreas, thymus, prostate, testis, ovary, small intestine & colon
- highest levels in adipose tissue, small intestine & colon
General
apoptosis related protein
phosphoprotein
secreted frizzled-related protein (sFRP) family
Properties
SIZE: entity length = 295 aa
MW = 33 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
frizzled domain {35-155}
MOTIF: cysteine residue {C40}
MODIFICATION: cysteine residue {C103}
cysteine residue {C50}
MODIFICATION: cysteine residue {C96}
cysteine residue {C87}
MODIFICATION: cysteine residue {C125}
cysteine residue {C96}
MODIFICATION: cysteine residue {C50}
cysteine residue {C103}
MODIFICATION: cysteine residue {C40}
cysteine residue {C114}
MODIFICATION: cysteine residue {C152}
cysteine residue {C118}
MODIFICATION: cysteine residue {C142}
cysteine residue {C125}
MODIFICATION: cysteine residue {C87}
cysteine residue {C142}
MODIFICATION: cysteine residue {C118}
cysteine residue {C152}
MODIFICATION: cysteine residue {C114}
NTR {172-295}
MOTIF: cysteine residue {C172}
MODIFICATION: cysteine residue {C245}
cysteine residue {C175}
MODIFICATION: cysteine residue {C247}
cysteine residue {C190}
MODIFICATION: cysteine residue {C295}
cysteine residue {C245}
MODIFICATION: cysteine residue {C172}
cysteine residue {C247}
MODIFICATION: cysteine residue {C175}
Ser phosphorylation site {S289}
cysteine residue {C295}
MODIFICATION: cysteine residue {C190}
Database Correlations
OMIM 604157
UniProt Q96HF1
PFAM correlations
Entrez Gene 6423
Kegg hsa:6423
References
UniProt :accession Q96HF1