secreted frizzled-related protein (sFRP) family

Function: - inhibitor of Wnt signaling - may function either by interacting with Wnt preventing binding to frizzled or forming nonfunctional complexes with frizzled Structure: - in addition to sRFP1-5, other family members include sizzled-1 & sizzled-2 & crescent, homologs of which have not been identified in mammals Compartment: secreted

Specific

secreted frizzled-related protein 1; FRP-1; sFRP-1; secreted apoptosis-related protein 2; SARP-2 (SFRP1, FRP, FRP1, SARP2) secreted frizzled-related protein 2; FRP-2; sFRP-2; secreted apoptosis-related protein 1; SARP-1 (SFRP2, FRP2, SARP1, FKSG12, UNQ361/PRO697) secreted frizzled-related protein 3; sFRP-3; Frezzled; Fritz; FrzB-1 (FRZB FIZ FRE FRP FRZB1 SFRP3) secreted frizzled-related protein 4; sFRP-4; Frizzled protein, human endometrium; FrpHE (SFRP4, FRPHE) secreted frizzled-related protein 5; sFRP-5; Frizzled-related protein 1b; FRP-1b; secreted apoptosis-related protein 3; SARP-3 (SFRP5, FRP1B, SARP3)

Properties

COMPARTMENT: extracellular compartment

References

- Kawano Y & Kypta R Secreted antagonists of the Wnt signalling pathway. J Cell Sci 116:2627-2634, 2003 PMID: 12775774