selenocysteine insertion sequence-binding protein 2; SECIS-binding protein 2 (SECISBP2, SBP2)

Function: - binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins; binding is stimulated by SELB - interacts with SELB (putative) Compartment: nucleus (putative) Alternative splicing: named isoforms=2 Expression: expressed at high levels in testis Pathology: - defects in SECISBP2 are a cause of abnormal thyroid hormone metabolism

General

nuclear protein RNA-binding protein

Properties

SIZE: entity length = 854 aa MW = 95 kD COMPARTMENT: cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl nuclear translocation signal {380-387} MOTIF: lysine-rich region {380-387} MOTIF: lysine residue (SEVERAL) binding site SITE: 673-694 FOR-BINDING-OF: ribonucleic acid

Database Correlations

OMIM correlations UniProt Q96T21 Pfam PF01248 Entrez Gene 79048 Kegg hsa:79048

References

UniProt :accession Q96T21