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SCO-spondin (SSPO)
Function:
- role in modulation of neuronal aggregation
- role in developmental events during formation of the central nervous system
Structure:
- belongs to the thrombospondin family
- contains 1 CTCK domain (C-terminal cystine knot-like domain)
- contains 2 EGF-like domains
- contains 1 EMI domain
- contains 1 F5/8 type C domain
- contains 10 LDL-receptor class A domains
- contains 6 TIL domains (trypsin inhibitory-like domains)
- contains 24 TSP type-1 domains
- contains 3 VWFC domains
- contains 3 VWFD domains
Compartment: secreted
General
glycoprotein
secreted protein
Properties
SIZE: MW = 548 kD
entity length = 5147 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-17}
EMI {18-102}
MOTIF: N-glycosylation site {N88}
N-glycosylation site {N130}
VWFD domain {194-408}
MOTIF: N-glycosylation site {N261}
TIL 1 {469-524}
MOTIF: N-glycosylation site {N514}
VWFD domain {563-773}
N-glycosylation site {N819}
TIL 2 {827-879}
VWFC domain {880-939}
MOTIF: N-glycosylation site {N911}
N-glycosylation site {N944}
N-glycosylation site {N986}
VWFD domain {1013-1219}
TIL 3 {1275-1331}
N-glycosylation site {N1352}
LDL-receptor class A {1375-1412}
MOTIF: cysteine residue {C1376}
MODIFICATION: cysteine residue {C1389}
cysteine residue {C1383}
MODIFICATION: cysteine residue {C1402}
cysteine residue {C1389}
MODIFICATION: cysteine residue {C1376}
cysteine residue {C1396}
MODIFICATION: cysteine residue {C1411}
cysteine residue {C1402}
MODIFICATION: cysteine residue {C1383}
cysteine residue {C1411}
MODIFICATION: cysteine residue {C1396}
LDL-receptor class A {1415-1450}
MOTIF: cysteine residue {C1416}
MODIFICATION: cysteine residue {C1428}
cysteine residue {C1423}
MODIFICATION: cysteine residue {C1441}
cysteine residue {C1428}
MODIFICATION: cysteine residue {C1416}
cysteine residue {C1441}
MODIFICATION: cysteine residue {C1423}
LDL-receptor class A {1451-1487}
MOTIF: cysteine residue {C1452}
MODIFICATION: cysteine residue {C1464}
cysteine residue {C1459}
MODIFICATION: cysteine residue {C1477}
cysteine residue {C1464}
MODIFICATION: cysteine residue {C1452}
cysteine residue {C1471}
MODIFICATION: cysteine residue {C1486}
cysteine residue {C1477}
MODIFICATION: cysteine residue {C1459}
cysteine residue {C1486}
MODIFICATION: cysteine residue {C1471}
LDL-receptor class A {1491-1529}
MOTIF: cysteine residue {C1492}
MODIFICATION: cysteine residue {C1504}
cysteine residue {C1499}
MODIFICATION: cysteine residue {C1517}
cysteine residue {C1504}
MODIFICATION: cysteine residue {C1492}
cysteine residue {C1511}
MODIFICATION: cysteine residue {C1528}
cysteine residue {C1517}
MODIFICATION: cysteine residue {C1499}
cysteine residue {C1528}
MODIFICATION: cysteine residue {C1511}
LDL-receptor class A {1564-1600}
MOTIF: cysteine residue {C1565}
MODIFICATION: cysteine residue {C1577}
cysteine residue {C1572}
MODIFICATION: cysteine residue {C1590}
cysteine residue {C1577}
MODIFICATION: cysteine residue {C1565}
cysteine residue {C1584}
MODIFICATION: cysteine residue {C1599}
cysteine residue {C1590}
MODIFICATION: cysteine residue {C1572}
cysteine residue {C1599}
MODIFICATION: cysteine residue {C1584}
LDL-receptor class A {1602-1641}
MOTIF: cysteine residue {C1603}
MODIFICATION: cysteine residue {C1616}
cysteine residue {C1610}
MODIFICATION: cysteine residue {C1629}
cysteine residue {C1616}
MODIFICATION: cysteine residue {C1603}
cysteine residue {C1623}
MODIFICATION: cysteine residue {C1640}
cysteine residue {C1629}
MODIFICATION: cysteine residue {C1610}
cysteine residue {C1640}
MODIFICATION: cysteine residue {C1623}
N-glycosylation site {N1650}
LDL-receptor class A {1655-1693}
MOTIF: cysteine residue {C1656}
MODIFICATION: cysteine residue {C1666}
cysteine residue {C1661}
MODIFICATION: cysteine residue {C1679}
N-glycosylation site {N1663}
cysteine residue {C1666}
MODIFICATION: cysteine residue {C1656}
cysteine residue {C1673}
MODIFICATION: cysteine residue {C1694}
cysteine residue {C1679}
MODIFICATION: cysteine residue {C1661}
TSP type-1 1 {1694-1748}
MOTIF: cysteine residue {C1694}
MODIFICATION: cysteine residue {C1673}
cysteine residue {C1706}
MODIFICATION: cysteine residue {C1742}
cysteine residue {C1710}
MODIFICATION: cysteine residue {C1747}
cysteine residue {C1721}
MODIFICATION: cysteine residue {C1732}
cysteine residue {C1732}
MODIFICATION: cysteine residue {C1721}
cysteine residue {C1742}
MODIFICATION: cysteine residue {C1706}
cysteine residue {C1747}
MODIFICATION: cysteine residue {C1710}
TSP type-1 2 {1750-1808}
MOTIF: cysteine residue {C1762}
MODIFICATION: cysteine residue {C1802}
cysteine residue {C1766}
MODIFICATION: cysteine residue {C1807}
cysteine residue {C1776}
MODIFICATION: cysteine residue {C1786}
cysteine residue {C1786}
MODIFICATION: cysteine residue {C1776}
cysteine residue {C1802}
MODIFICATION: cysteine residue {C1762}
cysteine residue {C1807}
MODIFICATION: cysteine residue {C1766}
N-glycosylation site {N1809}
EGF domain {1824-1863}
MOTIF: cysteine residue {C1828}
MODIFICATION: cysteine residue {C1843}
cysteine residue {C1837}
MODIFICATION: cysteine residue {C1848}
cysteine residue {C1843}
MODIFICATION: cysteine residue {C1828}
cysteine residue {C1848}
MODIFICATION: cysteine residue {C1837}
cysteine residue {C1850}
MODIFICATION: cysteine residue {C1862}
cysteine residue {C1862}
MODIFICATION: cysteine residue {C1850}
EGF domain {1864-1901}
MOTIF: cysteine residue {C1868}
MODIFICATION: cysteine residue {C1887}
cysteine residue {C1870}
MODIFICATION: cysteine residue {C1890}
cysteine residue {C1887}
MODIFICATION: cysteine residue {C1868}
cysteine residue {C1890}
MODIFICATION: cysteine residue {C1870}
cysteine residue {C1892}
MODIFICATION: cysteine residue {C1900}
cysteine residue {C1900}
MODIFICATION: cysteine residue {C1892}
TSP type-1 3 {1909-1965}
MOTIF: cysteine residue {C1910}
MODIFICATION: cysteine residue {C1949}
cysteine residue {C1921}
MODIFICATION: cysteine residue {C1925}
cysteine residue {C1925}
MODIFICATION: cysteine residue {C1921}
cysteine residue {C1949}
MODIFICATION: cysteine residue {C1910}
cysteine residue {C1959}
MODIFICATION: cysteine residue {C1964}
cysteine residue {C1964}
MODIFICATION: cysteine residue {C1959}
VWFC domain {1965-2025}
MOTIF: N-glycosylation site {N1993}
N-glycosylation site {N2030}
coagulation factors 5/8 type C domain (FA58C) {2065-2224}
MOTIF: cysteine residue {C2065}
MODIFICATION: cysteine residue {C2224}
N-glycosylation site {N2133}
cysteine residue {C2224}
MODIFICATION: cysteine residue {C2065}
LDL-receptor class A {2233-2269}
MOTIF: cysteine residue {C2234}
MODIFICATION: cysteine residue {C2246}
cysteine residue {C2241}
MODIFICATION: cysteine residue {C2259}
cysteine residue {C2246}
MODIFICATION: cysteine residue {C2234}
cysteine residue {C2253}
MODIFICATION: cysteine residue {C2268}
cysteine residue {C2259}
MODIFICATION: cysteine residue {C2241}
cysteine residue {C2268}
MODIFICATION: cysteine residue {C2253}
LDL-receptor class A {2390-2426}
MOTIF: cysteine residue {C2391}
MODIFICATION: cysteine residue {C2403}
cysteine residue {C2398}
MODIFICATION: cysteine residue {C2416}
cysteine residue {C2403}
MODIFICATION: cysteine residue {C2391}
cysteine residue {C2410}
MODIFICATION: cysteine residue {C2425}
cysteine residue {C2416}
MODIFICATION: cysteine residue {C2398}
cysteine residue {C2425}
MODIFICATION: cysteine residue {C2410}
LDL-receptor class A {2463-2499}
MOTIF: cysteine residue {C2464}
MODIFICATION: cysteine residue {C2476}
cysteine residue {C2471}
MODIFICATION: cysteine residue {C2489}
cysteine residue {C2476}
MODIFICATION: cysteine residue {C2464}
cysteine residue {C2483}
MODIFICATION: cysteine residue {C2498}
cysteine residue {C2489}
MODIFICATION: cysteine residue {C2471}
cysteine residue {C2498}
MODIFICATION: cysteine residue {C2483}
TSP type-1 4 {2500-2553}
MOTIF: cysteine residue {C2501}
MODIFICATION: cysteine residue {C2537}
cysteine residue {C2512}
MODIFICATION: cysteine residue {C2516}
cysteine residue {C2516}
MODIFICATION: cysteine residue {C2512}
cysteine residue {C2537}
MODIFICATION: cysteine residue {C2501}
cysteine residue {C2547}
MODIFICATION: cysteine residue {C2552}
cysteine residue {C2552}
MODIFICATION: cysteine residue {C2547}
TSP type-1 5 {2555-2610}
MOTIF: cysteine residue {C2567}
MODIFICATION: cysteine residue {C2604}
cysteine residue {C2571}
MODIFICATION: cysteine residue {C2609}
cysteine residue {C2582}
MODIFICATION: cysteine residue {C2594}
cysteine residue {C2594}
MODIFICATION: cysteine residue {C2582}
cysteine residue {C2604}
MODIFICATION: cysteine residue {C2567}
cysteine residue {C2609}
MODIFICATION: cysteine residue {C2571}
TIL 4 {2633-2675}
MOTIF: N-glycosylation site {N2645}
N-glycosylation site {N2694}
TSP type-1 6 {2715-2769}
MOTIF: cysteine residue {C2716}
MODIFICATION: cysteine residue {C2754}
cysteine residue {C2727}
MODIFICATION: cysteine residue {C2731}
cysteine residue {C2731}
MODIFICATION: cysteine residue {C2727}
cysteine residue {C2754}
MODIFICATION: cysteine residue {C2716}
cysteine residue {C2764}
MODIFICATION: cysteine residue {C2768}
cysteine residue {C2768}
MODIFICATION: cysteine residue {C2764}
TSP type-1 7 {2772-2828}
MOTIF: cysteine residue {C2784}
MODIFICATION: cysteine residue {C2822}
cysteine residue {C2788}
MODIFICATION: cysteine residue {C2827}
cysteine residue {C2804}
MODIFICATION: cysteine residue {C2812}
cysteine residue {C2812}
MODIFICATION: cysteine residue {C2804}
cysteine residue {C2822}
MODIFICATION: cysteine residue {C2784}
cysteine residue {C2827}
MODIFICATION: cysteine residue {C2788}
TSP type-1 8 {2830-2883}
MOTIF: cysteine residue {C2842}
MODIFICATION: cysteine residue {C2877}
cysteine residue {C2846}
MODIFICATION: cysteine residue {C2882}
cysteine residue {C2857}
MODIFICATION: cysteine residue {C2867}
cysteine residue {C2867}
MODIFICATION: cysteine residue {C2857}
cysteine residue {C2877}
MODIFICATION: cysteine residue {C2842}
cysteine residue {C2882}
MODIFICATION: cysteine residue {C2846}
N-glycosylation site {N2936}
N-glycosylation site {N2967}
TSP type-1 9 {2985-3040}
MOTIF: cysteine residue {C2986}
MODIFICATION: cysteine residue {C3024}
cysteine residue {C2997}
MODIFICATION: cysteine residue {C3001}
cysteine residue {C3001}
MODIFICATION: cysteine residue {C2997}
cysteine residue {C3024}
MODIFICATION: cysteine residue {C2986}
cysteine residue {C3034}
MODIFICATION: cysteine residue {C3039}
cysteine residue {C3039}
MODIFICATION: cysteine residue {C3034}
TSP type-1 10 {3041-3083}
MOTIF: N-glycosylation site {N3062}
N-glycosylation site {N3116}
N-glycosylation site {N3163}
N-glycosylation site {N3173}
TSP type-1 11 {3183-3250}
MOTIF: cysteine residue {C3195}
MODIFICATION: cysteine residue {C3244}
cysteine residue {C3199}
MODIFICATION: cysteine residue {C3249}
cysteine residue {C3210}
MODIFICATION: cysteine residue {C3234}
cysteine residue {C3234}
MODIFICATION: cysteine residue {C3210}
cysteine residue {C3244}
MODIFICATION: cysteine residue {C3195}
cysteine residue {C3249}
MODIFICATION: cysteine residue {C3199}
TSP type-1 12 {3252-3307}
MOTIF: cysteine residue {C3264}
MODIFICATION: cysteine residue {C3301}
cysteine residue {C3268}
MODIFICATION: cysteine residue {C3306}
cysteine residue {C3279}
MODIFICATION: cysteine residue {C3291}
cysteine residue {C3291}
MODIFICATION: cysteine residue {C3279}
cysteine residue {C3301}
MODIFICATION: cysteine residue {C3264}
cysteine residue {C3306}
MODIFICATION: cysteine residue {C3268}
N-glycosylation site {N3310}
TIL 5 {3311-3365}
N-glycosylation site {N3399}
TSP type-1 13 {3408-3470}
MOTIF: cysteine residue {C3420}
MODIFICATION: cysteine residue {C3463}
cysteine residue {C3424}
MODIFICATION: cysteine residue {C3469}
cysteine residue {C3435}
MODIFICATION: cysteine residue {C3447}
cysteine residue {C3447}
MODIFICATION: cysteine residue {C3435}
cysteine residue {C3463}
MODIFICATION: cysteine residue {C3420}
cysteine residue {C3469}
MODIFICATION: cysteine residue {C3424}
TSP type-1 14 {3472-3527}
MOTIF: cysteine residue {C3484}
MODIFICATION: cysteine residue {C3519}
cysteine residue {C3487}
MODIFICATION: cysteine residue {C3526}
cysteine residue {C3497}
MODIFICATION: cysteine residue {C3509}
cysteine residue {C3509}
MODIFICATION: cysteine residue {C3497}
N-glycosylation site {N3512}
cysteine residue {C3519}
MODIFICATION: cysteine residue {C3484}
N-glycosylation site {N3522}
cysteine residue {C3526}
MODIFICATION: cysteine residue {C3487}
N-glycosylation site {N3599}
N-glycosylation site {N3626}
TSP type-1 15 {3645-3693}
MOTIF: cysteine residue {C3657}
MODIFICATION: cysteine residue {C3687}
cysteine residue {C3661}
MODIFICATION: cysteine residue {C3692}
cysteine residue {C3672}
MODIFICATION: cysteine residue {C3677}
cysteine residue {C3677}
MODIFICATION: cysteine residue {C3672}
cysteine residue {C3687}
MODIFICATION: cysteine residue {C3657}
cysteine residue {C3692}
MODIFICATION: cysteine residue {C3661}
N-glycosylation site {N3792}
TSP type-1 16 {3811-3932}
MOTIF: cysteine residue {C3823}
MODIFICATION: cysteine residue {C3926}
cysteine residue {C3827}
MODIFICATION: cysteine residue {C3931}
cysteine residue {C3839}
MODIFICATION: cysteine residue {C3851}
cysteine residue {C3851}
MODIFICATION: cysteine residue {C3839}
N-glycosylation site {N3914}
cysteine residue {C3926}
MODIFICATION: cysteine residue {C3823}
cysteine residue {C3931}
MODIFICATION: cysteine residue {C3827}
TSP type-1 17 {3946-4002}
MOTIF: N-glycosylation site {N3946}
cysteine residue {C3947}
MODIFICATION: cysteine residue {C3983}
cysteine residue {C3958}
MODIFICATION: cysteine residue {C3962}
cysteine residue {C3962}
MODIFICATION: cysteine residue {C3958}
cysteine residue {C3983}
MODIFICATION: cysteine residue {C3947}
cysteine residue {C3996}
MODIFICATION: cysteine residue {C4001}
cysteine residue {C4001}
MODIFICATION: cysteine residue {C3996}
TSP type-1 18 {4004-4059}
MOTIF: cysteine residue {C4016}
MODIFICATION: cysteine residue {C4053}
cysteine residue {C4020}
MODIFICATION: cysteine residue {C4058}
cysteine residue {C4031}
MODIFICATION: cysteine residue {C4043}
cysteine residue {C4043}
MODIFICATION: cysteine residue {C4031}
cysteine residue {C4053}
MODIFICATION: cysteine residue {C4016}
cysteine residue {C4058}
MODIFICATION: cysteine residue {C4020}
N-glycosylation site {N4139}
TSP type-1 19 {4159-4212}
MOTIF: cysteine residue {C4160}
MODIFICATION: cysteine residue {C4196}
cysteine residue {C4171}
MODIFICATION: cysteine residue {C4175}
cysteine residue {C4175}
MODIFICATION: cysteine residue {C4171}
cysteine residue {C4196}
MODIFICATION: cysteine residue {C4160}
cysteine residue {C4206}
MODIFICATION: cysteine residue {C4211}
cysteine residue {C4211}
MODIFICATION: cysteine residue {C4206}
TSP type-1 20 {4253-4305}
TSP type-1 21 {4307-4363}
MOTIF: N-glycosylation site {N4346}
TSP type-1 22 {4365-4419}
MOTIF: cysteine residue {C4366}
MODIFICATION: cysteine residue {C4403}
cysteine residue {C4377}
MODIFICATION: cysteine residue {C4379}
cysteine residue {C4379}
MODIFICATION: cysteine residue {C4377}
cysteine residue {C4403}
MODIFICATION: cysteine residue {C4366}
cysteine residue {C4413}
MODIFICATION: cysteine residue {C4418}
N-glycosylation site {N4417}
cysteine residue {C4418}
MODIFICATION: cysteine residue {C4413}
TSP type-1 23 {4615-4665}
TIL 6 {4667-4723}
N-glycosylation site {N4731}
N-glycosylation site {N4748}
N-glycosylation site {N4753}
TSP type-1 24 {4763-4816}
MOTIF: cysteine residue {C4775}
MODIFICATION: cysteine residue {C4810}
cysteine residue {C4779}
MODIFICATION: cysteine residue {C4815}
cysteine residue {C4790}
MODIFICATION: cysteine residue {C4799}
cysteine residue {C4799}
MODIFICATION: cysteine residue {C4790}
cysteine residue {C4810}
MODIFICATION: cysteine residue {C4775}
cysteine residue {C4815}
MODIFICATION: cysteine residue {C4779}
N-glycosylation site {N4863}
N-glycosylation site {N4903}
N-glycosylation site {N4948}
N-glycosylation site {N4955}
VWFC domain {4984-5042}
C-terminal cystine knot {5041-5140}
MOTIF: cysteine residue {C5041}
MODIFICATION: cysteine residue {C5101}
N-glycosylation site {N5061}
cysteine residue {C5067}
MODIFICATION: cysteine residue {C5118}
cysteine residue {C5077}
MODIFICATION: cysteine residue {C5134}
cysteine residue {C5081}
MODIFICATION: cysteine residue {C5136}
cysteine residue {C5101}
MODIFICATION: cysteine residue {C5041}
cysteine residue {C5118}
MODIFICATION: cysteine residue {C5067}
cysteine residue {C5134}
MODIFICATION: cysteine residue {C5077}
cysteine residue {C5136}
MODIFICATION: cysteine residue {C5081}
Database Correlations
UniProt A2VEC9
PFAM correlations
References
UniProt :accession A2VEC9