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scl proto-oncogene protein; stem cell protein; T-cell leukemia/lymphoma-5 protein; T-cell acute lymphocytic leukemia-1 protein; TAL1 (SCL, TCL5)

Function: - may play role in hematopoietic differentiation - positive regulator of erythroid differentiation - efficient DNA binding requires dimerization with another bHLH protein - forms heterodimers with TCF3 - binds to the LIM domain containing protein LMO2 & to DRG1 - can assemble in a complex with LDB1 & LMO2. - component of a TAL1 complex composed at least of CBFA2T3, LDB1, TAL1 & TCF3 (putative) - phosphorylated on serine residues. phosphorylation of Ser-122 - strongly stimulated by hypoxia (putative) - ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122; ubiquitination targets the protein for rapid degradation via the ubiquitin system; process may be characteristic of microvascular endothelial cells, since not observed in large vessel endothelial cells (putative) Structure: - helix-loop-helix domain is necessary & sufficient for interaction with DRG1 - contains 1 basic helix-loop-helix (bHLH) domain Compartment: nucleus (putative) Alternative splicing: - named isoforms=3 - splicing pattern is cell-lineage dependent Expression: leukemic stem cell Pathology: - implicated in the genesis of hematopoietic malignancies - chromosomal translocation t(1;14)(p32;q11) involving TAL1 with T-cell receptor alpha chain (TCRA) gene may be a cause of acute lymphoblastic leukemia

Related

hematopoietic stem cell leukemia [SCL] gene, tal1 or TCL5

General

basic helix loop helix (bHLH) family transcription factor proto oncogene protein transcription factor (TF)

Properties

SIZE: entity length = 331 aa MW = 34 kD COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 89-132 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S122} DNA-binding motif SITE: 187-199 helix-loop-helix NAME: helix-loop-helix SITE: 200-240 FOR-BINDING-VIA: helix-loop-helix glycine-rich region {263-274}

Database Correlations

OMIM 187040 UniProt P17542 Pfam PF00010 Kegg hsa:6886

References

  1. Aplan PD, Lombardi DP, Ginsberg AM, Cossman J, Bertness VL, Kirsch IR. Disruption of the human SCL locus by "illegitimate" V-(D)-J recombinase activity. Science. 1990 Dec 7;250(4986):1426-9. PMID: 2255914
  2. Hunter T. Cooperation between oncogenes. Cell. 1991 Jan 25;64(2):249-70. Review. PMID: 1988147
  3. Atlas of genetics & cytogenetics in oncology & haematology http://atlasgeneticsoncology.org/genes/TAL1.html
  4. UniProt :accession P17542