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hematopoietic stem cell leukemia [SCL] gene, tal1 or TCL5
1p32
Function:
- probably encodes a hematopoietic transcription factor involved in early hematopoiesis
Pathology:
- gene origionally identified at the site of a 1;14 translocation associated with a hematopoietic stem cell leukemia
Related
scl proto-oncogene protein; stem cell protein; T-cell leukemia/lymphoma-5 protein; T-cell acute lymphocytic leukemia-1 protein; TAL1 (SCL, TCL5)
sil proto-oncogene or SCL-interrupting locus gene
General
gene with TATA box
proto-oncogene
Properties
TEMPLATE-FOR: messenger RNA
TEMPLATE-FOR: scl proto-oncogene protein
LOCUS: human chromosome-1 P33
MOTIF: transcription factor binding site
transcriptional termination site
transcriptional start site
exon
intron
transcriptional termination site
Database Correlations
OMIM 187040
Entrez Gene 6886
References
- Aplan PD, Lombardi DP, Ginsberg AM, Cossman J, Bertness VL, Kirsch IR.
Disruption of the human SCL locus by "illegitimate" V-(D)-J
recombinase activity.
Science. 1990 Dec 7;250(4986):1426-9.
PMID: 2255914
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147