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sclerostin domain-containing protein 1 (ectodermal BMP inhibitor, ectodin, uterine sensitization-associated gene 1 protein, USAG-1, SOSTDC1, USAG1, CDA019)
Function:
- role in onset of endometrial receptivity for implantation or sensitization for decidual cell reaction
- enhances Wnt signaling & inhibits TGF-beta signaling
- directly antagonizes activity of BMP2, BMP4, BMP6 & BMP7 (dose-dependent), high affinity interactions
Structure:
- belongs to the sclerostin family
- contains 1 CTCK domain (C-terminal cystine knot-like domain)
Compartment: secreted
Expression: expressed in kidney > lung
General
glycoprotein
secreted protein
Properties
SIZE: MW = 23 kD
entity length = 206 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
N-glycosylation site {N47}
C-terminal cystine knot {75-170}
MOTIF: cysteine residue {C75}
MODIFICATION: cysteine residue {C133}
cysteine residue {C89}
MODIFICATION: cysteine residue {C147}
cysteine residue {C100}
MODIFICATION: cysteine residue {C163}
cysteine residue {C104}
MODIFICATION: cysteine residue {C165}
cysteine residue {C133}
MODIFICATION: cysteine residue {C75}
cysteine residue {C147}
MODIFICATION: cysteine residue {C89}
cysteine residue {C163}
MODIFICATION: cysteine residue {C100}
cysteine residue {C165}
MODIFICATION: cysteine residue {C104}
N-glycosylation site {N173}
Database Correlations
UniProt Q6X4U4
Pfam PF05463
References
UniProt :accession Q6X4U4