Search
scleromyxedema; lichen myxedematosus; papular mucinosis
Etiology:
- association with monoclonal gammopathy, paraproteinemia
- generally IgG lambda
- multiple myeloma
- AL amyloidosis [1]
Epidemiology:
- more common in men than women
Pathology:
- skin biopsy
- mucin deposition
- stellate fibrobasts in dermis (fibroblast proliferation)
- collagen deposition
- involves
a) nervous system
b) gastrointestinal system
c) cardiovascular system
* histopathology images [2]
Clinical manifestations:
- waxy, yellow-red papules over thickened skin (induration) of face, upper trunk, neck & arms
* images [2,3]
Laboratory:
1) see monoclonal gammopathy
a) serum protein electrophoresis
b) urine protein electrophoresis
c) immunofixation electrophoresis shows IgG lambda
2) skin biopsy
Related
myxedema; thyroid dermopathy (includes myxedema coma)
scleredema (Buschke disease)
scleroderma (diffuse cutaneous systemic sclerosis)
General
skin disease (dermatologic disorder, dermatopathy, dermatosis)
sclerosis
References
- Medical Knowledge Self Assessment Program (MKSAP) 15, 17, 18.
American College of Physicians, Philadelphia 2009, 2015, 2018
- Liotta EA, Elston DM (images)
Medscape: Lichen Myxedematosus
http://emedicine.medscape.com/article/1074545-overview
- DermNet NZ. Lichen myxoedematosus (images)
http://dermnetnz.org/immune/scleromyxoedema.html