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scavenger receptor class F member 2 (scavenger receptor expressed by endothelial cells 2 protein, SREC-2, SRECRP-1)
Function:
- probable adhesion protein
- mediates homophilic & heterophilic interactions via extracellular domain
- interacts with SCARF1
- interaction with SCARF1 stronger than the homophilic interaction with itself, is suppressed by the presence of SCARF1 ligand Ac-LDL
- in contrast to SCARF1, poorly mediates the binding & degradation of acetylated low density lipoprotein (Ac-LDL)
Structure:
- homophilic & heterophilic interaction via its extracellular domain
- contains 7 EGF-like domains
Compartment: membrane
Expression:
- predominantly expressed in endothelial cells
- expressed in heart, placenta, lung, kidney, spleen, small intestine & ovary
General
glycoprotein
scavenger receptor
Properties
SIZE: MW = 92 kD
entity length = 866 aa
COMPARTMENT: cellular membrane
MOTIF: EGF domain {76-403} (7)
MOTIF: cysteine residue {C80}
MODIFICATION: cysteine residue {C92}
N-glycosylation site {N83}
cysteine residue {C86}
MODIFICATION: cysteine residue {C98}
cysteine residue {C92}
MODIFICATION: cysteine residue {C80}
cysteine residue {C98}
MODIFICATION: cysteine residue {C86}
cysteine residue {C100}
MODIFICATION: cysteine residue {C109}
cysteine residue {C109}
MODIFICATION: cysteine residue {C100}
N-glycosylation site {N310}
N-glycosylation site {N365}
transmembrane domain {442-462}
proline-rich region
SITE: 648-847
MOTIF: proline residue (SEVERAL)
Database Correlations
UniProt Q96GP6
Pfam PF07974
Kegg hsa:9117
References
UniProt :accession Q96GP6