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scavenger receptor class F member 1 (endothelial cells scavenger receptor, acetyl LDL receptor, SCARF1, SREC, KIAA0149)
Function:
- mediates the binding & degradation of acetylated low density lipoprotein (Ac-LDL).
- mediates heterophilic interactions, suggesting a function as an adhesion protein
- heterophilic interaction with SCARF2 via extracellular domain, suppressed by Ac-LDL
Structure: contains 6 EGF-like domains
Compartment: membrane
Expression: endothelial cells
General
glycoprotein
scavenger receptor
Properties
SIZE: MW = 87 kD
entity length = 830 aa
COMPARTMENT: cellular membrane
MOTIF: EGF domain {53-382} (6)
MOTIF: cysteine residue {C57}
MODIFICATION: cysteine residue {C69}
cysteine residue {C63}
MODIFICATION: cysteine residue {C75}
cysteine residue {C69}
MODIFICATION: cysteine residue {C57}
cysteine residue {C75}
MODIFICATION: cysteine residue {C63}
cysteine residue {C77}
MODIFICATION: cysteine residue {C86}
cysteine residue {C86}
MODIFICATION: cysteine residue {C77}
N-glycosylation site {N289}
N-glycosylation site {N393}
transmembrane domain {422-442}
MOTIF: leucine residue {431-438} (6)
serine-rich region {476-620}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S606}
Ser phosphorylation site {S611}
glycine-rich region {622-798}
Database Correlations
OMIM 607873
UniProt Q14162
PFAM correlations
Kegg hsa:8578
References
UniProt :accession Q14162