Contents

Search

scavenger receptor class B member 1 (SRB1, CD36 antigen-like 1, CD36 & LIMP2 analogous 1, CLA-1, collagen type I receptor - thrombospondin receptor-like 1, SCARB1, CD36L1, CLA1, CLA2)

Function: - probable HDL receptor - receptor for phospholipids, cholesterol ester, lipoproteins, phosphatidylserine & apoptotic cells - facilitates the flux of free & esterified cholesterol between cell surface & HDL & to a lesser extent, apoB-containing lipopoteins - involved in the phagocytosis of apoptotic cells, via phosphatidylserine binding - C-terminal region binds to PDZK1 (putative) Structure: - N-glycosylated - belongs to the CD36 family Compartment: - cell membrane - predominantly localized to aveolae Alternative splicing: named isoforms=4 Expression: - widely expressed Polymorphism: - the Ser-2 variant is associated with higher plasma triglyceride concentration in subjects with heterozygous familial hypercholesterolemia Pathology: - receptor for hepatitis C virus glycoprotein E2 - role in HCV attachment &/or cell entry by interacting with HCV E1/E2 glycoproteins heterodimer - variant in SCARB1 raises HDL cholesterol & increases risk of coronary heart disease [2]

Related

CD36; platelet glycoprotein 4; platelet glycoprotein IV; GPIV; glycoprotein IIIb; GPIIIB; leukocyte differentiation antigen CD36; PAS IV; PAS-4; platelet collagen receptor; fatty acid translocase; FAT; Thrombospondin receptor (GP3B, GP4)

General

glycoprotein scavenger receptor transmembrane 2 protein

Properties

SIZE: MW = 61 kD entity length = 552 aa COMPARTMENT: cellular membrane MOTIF: cytoplasmic domain {1-11} transmembrane domain {12-32} exoplasmic loop {33-443} MOTIF: N-glycosylation site {N102} N-glycosylation site {N108} N-glycosylation site {N173} N-glycosylation site {N212} N-glycosylation site {N227} N-glycosylation site {N255} N-glycosylation site {N310} N-glycosylation site {N330} N-glycosylation site {N383} transmembrane domain {444-464} cytoplasmic domain {465-552}

Database Correlations

OMIM 601040 UniProt Q8WTV0 Pfam PF01130

References

  1. UniProt :accession Q8WTV0
  2. Zanoni P et al Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease. Science. 2016 March 11 351(6278):1166-71 PMID: 26965621 http://science.sciencemag.org/content/351/6278/1166