Search
scalp cooling system; cooling cap (DigniCap)
Indication:
- reduction of chemotherapy (taxane)-related alopecia in women treated for breast cancer [1,2]
Procedure:
- cooling device is a two-cap system:
- an inner silicon cap circulates a refrigerated fluid
- an outer neoprene cap acts as an insulator
- device worn during chemotherapy, 30 minutes before & 90 minutes afterward [2]
Mechanism of action:
- lowers temperature of scalp
- diminishes blood flow to the scalp
- reduces amount of chemotherapy reaching hair follicles [2]
* preserves hair in 50% of women
Notes:
- cost of $1500-3000/patient (2017) [3]
General
device (medical device)
References
- Dignitana Brings First and Only U.S. FDA-Cleared Scalp Cooling
System to Market.
DigniCap. Dec 8, 2015
http://www.dignicap.com/dignitana-fda-clearance/
- Orciari Herman A, Sadoughi S, Sofair A
Scalp-Cooling Device Limits Hair Loss from Chemotherapy.
Physician's First Watch, Dec 12, 2016
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- Huseman A
Scalp-cooling device cuts hair loss in breast cancer patients
undergoing chemotherapy.
Baylor College of Medicine News Release. Dec 9, 2016
https://www.bcm.edu/news/cancer/scalp-cooling-reduces-chemotherap-hair-loss
- Nangia J, Wang T, Osborne C et al
Effect of a Scalp Cooling Device on Alopecia in Women
Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized
Clinical Trial.
JAMA. 2017 Feb 14;317(6):596-605.
PMID: 28196254
http://jamanetwork.com/journals/jama/article-abstract/2601500
- Rugo HS, Klein P, Melin SA et al
Association Between Use of a Scalp Cooling Device and Alopecia
After Chemotherapy for Breast Cancer.
JAMA. 2017 Feb 14;317(6):606-614.
PMID: 28196257
http://jamanetwork.com/journals/jama/article-abstract/2601503
- Hershman DL.
Scalp Cooling to Prevent Chemotherapy-Induced Alopecia: The
Time Has Come.
JAMA. 2017 Feb 14;317(6):587-588.
PMID: 28196237
http://jamanetwork.com/journals/jama/article-abstract/2601483