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SARS CoV2 & pregnancy & breastfeeding

Laboratory: - maternal IgG antibodies to SARS-CoV2 are transferred across the placenta after asymptomatic as well as symptomatic infection during pregnancy [1] - cord blood antibody concentrations correlated with maternal antibody concentrations & with duration between onset of infection & delivery - SARS-CoV2 specific IgA & IgG antibodies found in breast milk for at least 6 weeks after COVID-19 vaccination [3] - IgA secretion found as early as 2 weeks after vaccination, IgG after 4 weeks (a week after the second Pfizer vaccine) Management: - mRNA Covid-19 vaccines safe during pregnancy [2]

Related

pregnancy (gestation)

General

severe acute respiratory syndrome coronavirus 2; SARS-CoV2; Wuhan coronavirus

References

  1. Flannery DD, Gouma S, Dhudasia MD et al Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. Published online January 29, 2021 PMID: 33512440 PMCID: PMC7846944 (available on 2022-01-29) https://jamanetwork.com/journals/jamapediatrics/fullarticle/2775945 - Munoz FM Can We Protect Pregnant Women and Young Infants From COVID-19 Through Maternal Immunization? JAMA Pediatr. Published online January 29, 2021 PMID: 33512398 https://jamanetwork.com/journals/jamapediatrics/fullarticle/2775944
  2. Shimabukuro TT, Kim SY, Myers TR et al Preliminary Findings of mRNA Covid-19 Vaccine Safety in Pregnant Persons. N Engl J Med. 2021. April 21. PMID: 33882218 https://www.nejm.org/doi/full/10.1056/NEJMoa2104983
  3. Perl SH, Uzan-Yulzari A, Klainer H et al SARS-CoV-2-Specific Antibodies in Breast Milk After COVID-19 Vaccination of Breastfeeding Women. JAMA. 2021;325(19):2013-2014 PMID: 33843975 PMCID: PMC8042567 (available on 2021-10-12) https://jamanetwork.com/journals/jama/fullarticle/2778766