SAM pointed domain-containing Ets transcription factor (prostate-derived Ets factor, prostate epithelium-specific Ets transcription factor, prostate-specific Ets, SPDEF, PDEF, PSE)

Function: 1) androgen-independent transactivator of the prostate-specific antigen (PSA) promoter (putative) 2) binds to 5'-GGAT-3' DNA sequences 3) regulation of prostate gland 4) transcriptional activator for SERPINB5 promoter 5) interacts with the DNA-binding domain of the androgen receptor 6) interacts with NKX3-1 Structure: 1) belongs to the ETS family 2) contains 1 ETS DNA-binding domain - contains 1 PNT (pointed) domain Compartment: nucleus Expression: - expressed in restricted set of primarily hormone-regulated epithelial tissues, prostate gland > mammary gland, salivary gland, ovary Pathology: 1) regulation of prostate cancer development (putative) 2) expressed in prostate carcinoma cells

General

DNA-binding protein transcription factor (TF)

Properties

SIZE: MW = 38 kD entity length = 335 aa COMPARTMENT: cell nucleus MOTIF: PNT {131-213} ETS domain NAME: ETS domain SITE: 249-332

Database Correlations

OMIM 608144 UniProt O95238 PFAM correlations

References

UniProt :accession O95238